Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23558
Abstract: Accumulating evidence indicates that neuroinflammation contributes to the pathogenesis and exacerbation of neurodegenerative disorders, such as Alzheimer's disease (AD). Sphingosine‐1‐phosphate (S1P) is a pleiotropic bioactive lipid that regulates many pathophysiological processes including inflammation. We present… read more here.
Keywords: promotes microglia; microglia pro; inflammatory activation; spns2 ... See more keywords
Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.
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DOI: 10.1021/acs.jmedchem.1c02171
Abstract: Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five G-protein-coupled receptors (S1P1-5) to regulate cellular signaling pathways. S1P export is facilitated by Mfsd2b and spinster homologue 2 (Spns2). While mouse genetic studies… read more here.
Keywords: spns2 inhibitors; spns2; biology; sphingosine phosphate ... See more keywords
S1P promotes corneal trigeminal neuron differentiation and corneal nerve repair via upregulating nerve growth factor expression in a mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0491
Abstract: Abstract Corneal disease was the most critical cause of vision loss. This study aimed to research a new method and provide a theoretical basis for treating corneal injury. A mice corneal epithelial injury model was… read more here.
Keywords: spns2; s1p; nerve; factor ... See more keywords