LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "spns2" as a keyword



Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide

Sign Up to like & get
recommendations! Published in 2019 at "Glia"

DOI: 10.1002/glia.23558

Abstract: Accumulating evidence indicates that neuroinflammation contributes to the pathogenesis and exacerbation of neurodegenerative disorders, such as Alzheimer's disease (AD). Sphingosine‐1‐phosphate (S1P) is a pleiotropic bioactive lipid that regulates many pathophysiological processes including inflammation. We present… read more here.

Keywords: promotes microglia; microglia pro; inflammatory activation; spns2 ... See more keywords

Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.

Sign Up to like & get
recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c02171

Abstract: Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five G-protein-coupled receptors (S1P1-5) to regulate cellular signaling pathways. S1P export is facilitated by Mfsd2b and spinster homologue 2 (Spns2). While mouse genetic studies… read more here.

Keywords: spns2 inhibitors; spns2; biology; sphingosine phosphate ... See more keywords

Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors

Sign Up to like & get
recommendations! Published in 2024 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.4c00879

Abstract: Targeting the S1P pathway has resulted in the development of S1P1 receptor modulators for the treatment of multiple sclerosis and ulcerative colitis. We hypothesize that targeting an upstream node of the S1P pathway may provide… read more here.

Keywords: bioavailable sphingosine; spns2; orally bioavailable; discovery potent ... See more keywords

S1P promotes corneal trigeminal neuron differentiation and corneal nerve repair via upregulating nerve growth factor expression in a mouse model

Sign Up to like & get
recommendations! Published in 2022 at "Open Life Sciences"

DOI: 10.1515/biol-2022-0491

Abstract: Abstract Corneal disease was the most critical cause of vision loss. This study aimed to research a new method and provide a theoretical basis for treating corneal injury. A mice corneal epithelial injury model was… read more here.

Keywords: spns2; s1p; nerve; factor ... See more keywords