Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.
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DOI: 10.1021/acs.jmedchem.1c02171
Abstract: Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five G-protein-coupled receptors (S1P1-5) to regulate cellular signaling pathways. S1P export is facilitated by Mfsd2b and spinster homologue 2 (Spns2). While mouse genetic studies… read more here.
Keywords: spns2 inhibitors; spns2; biology; sphingosine phosphate ... See more keywords