A potential prognostic marker and therapeutic target: SPOCK1 promotes the proliferation, metastasis, and apoptosis of pancreatic ductal adenocarcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29320
Abstract: Pancreatic ductal adenocarcinoma (PDAC), a common malignancy originated from the digestive system worldwide, has a poor clinical outcome. SPOCK1 is a widely investigated member of the Ca2+‐binding proteoglycan family and functions as an essential driver… read more here.
Keywords: proliferation metastasis; pancreatic ductal; spock1; ductal adenocarcinoma ... See more keywords
SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Laboratory Investigation"
DOI: 10.1038/s41374-020-0425-4
Abstract: Sparc/osteonectin, cwcv, and kazal-like domain proteoglycan 1 (SPOCK1) is a matricellular protein which regulates cell proliferation, invasion, and survival but the function of SPOCK1 in liver fibrosis is obscure. In this study, we found that… read more here.
Keywords: liver fibrosis; pi3k akt; signaling pathway; spock1 ... See more keywords
MiR-129-5p influences the progression of gastric cancer cells through interacting with SPOCK1
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DOI: 10.1177/1010428317706916
Abstract: The purpose of our study is to clarify the effect of microRNA-129-5p in the progression of human gastric cancer cells by regulating SPOCK1. The expression of microRNA-129-5p and SPOCK1 was tested by quantitative real-time polymerase… read more here.
Keywords: gastric cancer; microrna 129; spock1; cancer cells ... See more keywords
SPOCK1 Promotes the Development of Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.819883
Abstract: The extracellular matrix proteoglycan SPOCK1 is increasingly recognized as a contributor to the development and progression of cancers. Here, we study how SPOCK1, which is present in non-tumorous hepatocytes at low concentrations, promotes the development… read more here.
Keywords: cell; hepatocellular carcinoma; development; promotes development ... See more keywords
SPOCK1 Overexpression Suggests Poor Prognosis of Ovarian Cancer
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DOI: 10.3390/cancers15072037
Abstract: Simple Summary The SPOCK1 proteoglyan has been discovered as an oncogene with overexpression, promoting tumor formation and progression, and linked with poor survival rates. However, information on SPOCK1′s significance in ovarian cancer is limited. The… read more here.
Keywords: cell lines; ovarian cancer; overexpression; spock1 ... See more keywords