Conserved Proline Residues of Bacillus subtilis Intramembrane Metalloprotease SpoIVFB Are Important for Substrate Interaction and Cleavage
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00386-21
Abstract: Intramembrane metalloproteases (IMMPs) function in numerous signaling pathways. Bacterial IMMPs govern stress responses, including the sporulation of some species, thus enhancing the virulence and persistence of pathogens. ABSTRACT Intramembrane metalloproteases (IMMPs) regulate diverse biological processes… read more here.
Keywords: cleavage; proline residues; short loop; substrate ... See more keywords
Inhibitory proteins block substrate access by occupying the active site cleft of Bacillus subtilis intramembrane protease SpoIVFB
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74275
Abstract: Intramembrane proteases (IPs) function in numerous signaling pathways that impact health, but elucidating the regulation of membrane-embedded proteases is challenging. We examined inhibition of intramembrane metalloprotease SpoIVFB by proteins BofA and SpoIVFA. We found that… read more here.
Keywords: membrane embedded; inhibitory proteins; spoivfb; inhibition ... See more keywords