R-spondin 3 Inhibits High Glucose-Induced Endothelial Activation Through Leucine-Rich G Protein-Coupled Receptor 4/Wnt/β-catenin Pathway
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DOI: 10.1097/fjc.0000000000001295
Abstract: Abstract: High glucose-induced endothelial activation plays critical roles in the development of diabetic vascular complications. R-spondin 3 could inhibit inflammatory damage, and diabetic vascular inflammation is secondary to endothelial activation. In this article, we identify… read more here.
Keywords: glucose induced; spondin; high glucose; endothelial activation ... See more keywords
Identification and Validation of Immune Implication of R-Spondin 1 and an R-Spondin 1-Related Prognostic Signature in Esophagus Cancer
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DOI: 10.1155/2024/7974277
Abstract: R-spondin 1 (RSPO1), which encodes a secretory-activating protein, is a promising therapeutic target for various tumors. The aim of this study was to establish a robust RSPO1-related signature specific to esophageal cancer (ESCA). Our comprehensive… read more here.
Keywords: cancer; rspo1; rspo1 expression; signature ... See more keywords
Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
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DOI: 10.1158/1078-0432.ccr-21-3018
Abstract: Abstract Purpose: Gene fusions involving R-spondin (RSPOfp) and RNF43 mutations have been shown to drive Wnt-dependent tumor initiation in colorectal cancer. Herein, we aimed to characterize the molecular features of RSPOfp/RNF43 mutated (mut) compared with… read more here.
Keywords: rspofp rnf43; spondin; rnf43; rnf43 mutations ... See more keywords
Serum Spondin-2 expression, tumor invasion, and antitumor immune response in patients with cervical cancer
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DOI: 10.12998/wjcc.v10.i36.13304
Abstract: BACKGROUND Cervical cancer is a gynecological malignancy common in middle-aged and older patients, with a high mortality rate. Spondin-2 is an extracellular matrix protein that involved in innate and acquired immune responses. Herein, we investigated… read more here.
Keywords: cervical cancer; spondin; spondin group; serum spondin ... See more keywords