Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge Stylissa aff. carteri Collected off the Futuna Islands.
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DOI: 10.1021/acs.jnatprod.0c00223
Abstract: The chemical investigation of the sponge Stylissa aff. carteri collected around Futuna Islands in the Pacific Ocean led to the isolation of three new dimeric pyrrole 2-aminoimidazole alkaloids (PIAs). Futunamine (1) features an unprecedented pyrrolo[1,2-c]imidazole… read more here.
Keywords: carteri collected; futuna islands; stylissa aff; sponge stylissa ... See more keywords
A Series of New Pyrrole Alkaloids with ALR2 Inhibitory Activities from the Sponge Stylissa massa
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DOI: 10.3390/md20070454
Abstract: Twelve new and four known alkaloids including five different structural scaffolds were isolated from the sponge Stylissa massa collected in the South China Sea. Compound 1 is the first identified precursor metabolite of the classic… read more here.
Keywords: alr2 inhibitory; sponge stylissa; series new; stylissa massa ... See more keywords
GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge Stylissa sp. Extends Its Therapeutic Potential for Noncommunicable Diseases
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DOI: 10.3390/molecules26185618
Abstract: We report the first isolation of the alkaloid aaptamine from the Philippine marine sponge Stylissa sp. Aaptamine possessed weak antiproliferative activity against HCT116 colon cancer cells and inhibited the proteasome in vitro at 50 µM.… read more here.
Keywords: noncommunicable diseases; activity; sponge stylissa; aaptamine philippine ... See more keywords