5 LOSS OF ESTROGEN RECEPTOR BETA IN A SPONTANEOUS MODEL OF CROHN’S-LIKE ILEITIS REVEALS SEX-SPECIFIC FUNCTIONS OF ESTROGEN SIGNALING AMONG INTESTINAL REGULATORY T CELLS
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.11.107
Abstract: achieved endothelial LPP3 (ERT2-LPP3) deficiency in adult mice using a tamoxifen-inducible Cre transgene under the control of the Tyrosine kinase Tek promoter. Previously, we have shown that ERT2-LPP3 mice exhibited a three-fold increase in circulating… read more here.
Keywords: loss estrogen; beta spontaneous; spontaneous model; receptor beta ... See more keywords
A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53
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DOI: 10.1371/journal.pone.0193485
Abstract: Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model with which to study the biology of this disease and to develop therapeutics is lacking.… read more here.
Keywords: spontaneous model; model; model spondyloarthropathies; bone loss ... See more keywords
The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2017.00146
Abstract: Melanoma is the deadliest skin cancer and is a major public health concern with a growing incidence worldwide. As for other complex diseases, animal models are needed in order to better understand the mechanisms leading… read more here.
Keywords: spontaneous model; melim minipig; original spontaneous; model explore ... See more keywords