In vitro display evolution of unnatural peptides spontaneously cyclized via intramolecular nucleophilic aromatic substitutions.
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DOI: 10.1039/d2cc00584k
Abstract: We report novel, ribosomally incorporatable, and intramolecularly cysteine-reactive fluorobenzoic acid-derived linkers for SELEX of mRNA-displayed unnatural peptides, which spontaneously cyclized via intramolecular nucleophilic aromatic substitutions forming thioethers. With this strategy we identified several novel PCSK9-binding… read more here.
Keywords: intramolecular nucleophilic; unnatural peptides; peptides spontaneously; spontaneously cyclized ... See more keywords