Articles with "spontaneously cyclized" as a keyword



Photo by ankhesenamunnn from unsplash

In vitro display evolution of unnatural peptides spontaneously cyclized via intramolecular nucleophilic aromatic substitutions.

Sign Up to like & get
recommendations!
Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc00584k

Abstract: We report novel, ribosomally incorporatable, and intramolecularly cysteine-reactive fluorobenzoic acid-derived linkers for SELEX of mRNA-displayed unnatural peptides, which spontaneously cyclized via intramolecular nucleophilic aromatic substitutions forming thioethers. With this strategy we identified several novel PCSK9-binding… read more here.

Keywords: intramolecular nucleophilic; unnatural peptides; peptides spontaneously; spontaneously cyclized ... See more keywords