Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4884-4
Abstract: BackgroundElevated expression of matrix metalloproteinases (MMPs) is correlated with invasion and metastasis of colorectal cancer (CRC). Recently, a previous study has suggested that speckle-type POZ protein (SPOP) could inhibit cancer cell proliferation and migration through… read more here.
Keywords: pi3k akt; signaling pathway; expression; cancer ... See more keywords
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.027
Abstract: Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast, and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and localizes to nuclear speckles. Although cancer-associated mutations in… read more here.
Keywords: suppressor spop; tumor suppressor; mutations tumor; cancer ... See more keywords
Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.04.002
Abstract: Sonic Hedgehog (Shh) signaling regulates the patterning of ventral spinal cord through the effector Gli family of transcription factors. Previous in vitro studies showed that an E3 ubiquitin ligase containing Speckle-type POZ protein (Spop) targets… read more here.
Keywords: cord; shh signaling; spop; cord patterning ... See more keywords
TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07475-5
Abstract: TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa… read more here.
Keywords: trim24; prostate cancer; trim28; pca ... See more keywords
SPOP Inhibition of Endometrial Carcinoma and Its Clinicopathological Relationship
Sign Up to like & getrecommendations! Published in 2022 at "Applied Bionics and Biomechanics"
DOI: 10.1155/2022/5721630
Abstract: Objective Endometrial carcinoma (EC) ranks first in the incidence of female genital malignancies in developed countries. SPOP (speckle-type POZ protein) has changed in EC with a statistically high frequency. This research may play a crucial… read more here.
Keywords: endometrial carcinoma; expression; migration; invasion ... See more keywords
Deregulation of SPOP in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2801
Abstract: Speckle-type POZ protein (SPOP) is a substrate-binding adaptor of the CULLIN3/RING-box1 E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate cancer (PCa) and endometrial cancer (ECa) while it is overexpressed in renal cell carcinoma… read more here.
Keywords: spop; cancer; deregulation spop; spop cancer ... See more keywords
Abstract 1705: SPOP: An essential gene for normal and prostate tumor cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1705
Abstract: Background: Prostate cancer (PC) is the single most common and second-most lethal cancer in men, with over 268,000 estimated cases and over 34,500 estimated deaths in the US in 2022. The Speckle-Type POZ protein (SPOP)… read more here.
Keywords: gene; cell; prostate; normal prostate ... See more keywords
Abstract 937: Opposing roles of SPOP mutations in human prostate and endometrial cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-937
Abstract: Recurrent mutations in the gene encoding the Speckle Type POZ Protein, SPOP, the substrate-binding components of E3-ubiquitin ligase, have been identified as common alterations in prostate cancer (PCa) and endometrial cancer (EC). SPOP mutations are… read more here.
Keywords: spop mutations; opposing roles; pca; spop mutated ... See more keywords
Abstract A008: Elucidating the effects of the Alzheimer's disease associated gene BIN1 on cancer tumorigenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a008
Abstract: Purpose- BIN1 is in deleted in ~5% of all prostate cancer (PC) patients and interestingly is highly enriched in the Speckle-type POZ protein (SPOP) mutant subclass (15%) of PC. BIN1 was originally identified as a… read more here.
Keywords: gene; bin1; deletion; bin1 deletion ... See more keywords
Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119518
Abstract: Elevated levels of fetal hemoglobin (HbF) are beneficial to patients with sickle cell disease (SCD) and b-thalassemia. The identification of pharmacologically controllable pathways that regulate HbF levels remains an important goal in the treatment of… read more here.
Keywords: protein; hbf; ubiquitin ligase; depletion ... See more keywords
Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-017-1276-7
Abstract: BackgroundSpeckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it remains unclear if… read more here.
Keywords: mutant spop; spop mutations; spop proteins; prostate cancer ... See more keywords