Two distinct skeletal muscle microRNA signatures revealing the complex mechanism of sporadic ALS.
Sign Up to like & getrecommendations! Published in 2021 at "Acta neurologica Belgica"
DOI: 10.1007/s13760-021-01743-w
Abstract: Skeletal muscle pathology is thought to have an important role in the onset and/or progression of amyotrophic lateral sclerosis (ALS), which is a neurodegenerative disorder characterized by progressive muscle weakness. Since miRNAs are recognized as… read more here.
Keywords: skeletal muscle; muscle; mirnas patients; expressed mirnas ... See more keywords
Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures.
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.10.010
Abstract: Induced pluripotent stem cell (iPSC)-derived neural cultures from amyotrophic lateral sclerosis (ALS) patients can model disease phenotypes. However, heterogeneity arising from genetic and experimental variability limits their utility, impacting reproducibility and the ability to track… read more here.
Keywords: early convergent; disease; cross comparison; sporadic als ... See more keywords
Burden of rare variants in ALS genes influences survival in familial and sporadic ALS
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.06.007
Abstract: Genetic variants are implicated in the development of amyotrophic lateral sclerosis (ALS), but it is unclear whether the burden of rare variants in ALS genes has an effect on survival. We performed whole genome sequencing… read more here.
Keywords: als genes; burden rare; variants als; sporadic als ... See more keywords
A Study of Gene Expression Changes in Human Spinal and Oculomotor Neurons; Identifying Potential Links to Sporadic ALS
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11040448
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes compromised function of motor neurons and neuronal death. However, oculomotor neurons are largely spared from disease symptoms. The underlying causes for sporadic ALS as well… read more here.
Keywords: gene expression; oculomotor neurons; sporadic als; spinal oculomotor ... See more keywords