DNA base excision repair genetic risk scores, oxidative balance, and incident, sporadic colorectal adenoma
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DOI: 10.1002/mc.22620
Abstract: Associations of individual base excision repair (BER) genotypes with colorectal adenoma risk are unclear, but likely modest. However, genetic risk scores (GRS) that aggregate information from multiple genetic variants might be useful for assessing genetic… read more here.
Keywords: risk; adenoma; incident sporadic; base excision ... See more keywords
Alteration of the tumor suppressor SARDH in sporadic colorectal cancer: A functional and transcriptome profiling‐based study
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22984
Abstract: Sporadic colorectal cancer (sCRC) is one of the leading causes of cancer death worldwide. As a highly heterogeneous complex disease, the currently reported classical genetic markers for sCRC, including APC, KRAS, BRAF, and TP53 gene… read more here.
Keywords: tumor suppressor; sardh; colorectal cancer; sporadic colorectal ... See more keywords
Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61688-7
Abstract: Sporadic colorectal cancer (sCRC) is the third most frequent cancer worldwide and the second most common cause of cancer-related deaths (mainly due metastatic dissemination). We investigated the immunohistochemical expression of frequently altered proteins in primary… read more here.
Keywords: sporadic colorectal; copy number; expression; egfr expression ... See more keywords
Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer
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DOI: 10.1159/000494969
Abstract: Background: Although Gankyrin is overexpressed in many malignancies, the role of Gankyrin for tumorigenesis and chemoresistance remains to be elucidated in sporadic colorectal cancer (CRC). Aims: We investigate whether Gankyrin affects Adenomatous polyposis coli (Apc)… read more here.
Keywords: colorectal cancer; expression; sporadic colorectal; tumorigenesis chemoresistance ... See more keywords
Outcomes for matched patients with metastatic colitis-associated cancers versus sporadic colorectal cancer receiving chemotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15534
Abstract: e15534Background: Colitis-associated cancers (CAC) develop in the setting of inflammatory bowel disease (IBD) and have a distinct pathogenesis and genomic features compared to sporadic colorectal c... read more here.
Keywords: matched patients; sporadic colorectal; associated cancers; colitis associated ... See more keywords
Combined assessment of the TNM stage and BRAF mutational status at diagnosis in sporadic colorectal cancer patients
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DOI: 10.18632/oncotarget.25300
Abstract: The prognostic impact of KRAS mutations and other KRAS-related and non-related genes such as BRAF, NRAS and TP53, on sporadic colorectal cancer (sCRC) remain controversial and/or have not been fully established. Here we investigated the… read more here.
Keywords: colorectal cancer; tnm stage; braf mutational; sporadic colorectal ... See more keywords
Gut Microbiota Imbalance is Related to Sporadic Colorectal Neoplasms. A Pilot Study
Sign Up to like & getrecommendations! Published in 2019 at "Applied Sciences"
DOI: 10.3390/app9245491
Abstract: (1) Background: Colorectal cancer (CRC) development is sustained by multiple factors including the gut microbiota, as suggested by a growing body of evidence. Most CRCs have a sporadic (non-hereditary) onset and develop from sporadic colorectal… read more here.
Keywords: stool samples; sporadic colorectal; gut microbiota; study ... See more keywords
Mismatch repair protein deficiency assessed by immunohistochemistry in sporadic colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Indian Journal of Pathology and Microbiology"
DOI: 10.4103/ijpm.ijpm_531_21
Abstract: Context: Globally, colorectal carcinoma (CRC) ranks the third most commonly diagnosed malignant disease, one of the leading causes of cancer deaths. Aims: To study the spectrum of clinicopathological characteristics of sporadic colorectal carcinoma and to… read more here.
Keywords: sporadic colorectal; mismatch repair; colorectal carcinoma; carcinoma ... See more keywords