Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0420-y
Abstract: Alterations in microtubule-dependent transport, mitochondrial dysfunction, and autophagic pathology are involved in neurodegeneration observed in sporadic Parkinson’s disease. However, the mechanistic link connecting these events remains elusive. We observed that NAD+ metabolism is altered in… read more here.
Keywords: parkinson; sporadic parkinson; mitochondrial metabolism; parkinson disease ... See more keywords
TNF-α −308 G/A and −238 G/A promoter polymorphisms and sporadic Parkinson's disease in an Italian cohort
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.12.011
Abstract: The etiology of sporadic Parkinson's disease is (PD) still not understood but it is believed that a complex interplay between environmental and genetic factors could trigger the pathology. Pro-inflammatory TNF-α is released by activated microglia… read more here.
Keywords: tnf 308; sporadic parkinson; rs361525 rs1800629; disease ... See more keywords
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.01.020
Abstract: Summary Recent advances in generating three-dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling and drug screening because organoids can recapitulate aspects of in vivo architecture and physiology. In this study,… read more here.
Keywords: midbrain organoids; sporadic parkinson; disease; parkinson disease ... See more keywords
Author response: Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases
Sign Up to like & getrecommendations! Published in 2020 at "Neurology"
DOI: 10.1212/wnl.0000000000008822
Abstract: The data reviewed in our article1 raise the possibility that neuropathologic features in sporadic Parkinson disease (PD) and Alzheimer disease (AD) may be the result of a diverse set of biological processes.1 read more here.
Keywords: protein aggregation; author response; sporadic parkinson; response revisiting ... See more keywords
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.650371
Abstract: Many clinical symptoms of sporadic Parkinson’s disease (sPD) cannot be completely explained by a lesion of the simple typical extrapyramidal circuit between the striatum and substantia nigra. Therefore, this study aimed to explore the new… read more here.
Keywords: sporadic parkinson; structural connectivity; pathogenesis; cortical structural ... See more keywords