Whole transcriptome sequencing for revealing the pathogenesis of sporotrichosis caused by Sporothrix globosa
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DOI: 10.1038/s41598-023-50728-7
Abstract: This study aimed to investigate the molecular mechanism of sporotrichosis and identify possible novel therapeutic targets. Total RNA was extracted from skin lesion samples from sporotrichosis patients and used to construct a long-chain RNA transcriptome… read more here.
Keywords: sporotrichosis; sporothrix globosa; analysis; whole transcriptome ... See more keywords
Effects of the Novel Mitochondrial Targeted Compound Phosundoxin against Sporothrix globosa: Microbial Sensitivity Test combined with Transcriptomics and Proteomics.
Sign Up to like & getrecommendations! Published in 2025 at "Medical mycology"
DOI: 10.1093/mmy/myaf095
Abstract: In recent years, the resistance of Sporothrix globosa to antifungal treatments has steadily increased, while the cure rate for sporotrichosis has declined. This growing resistance underscores the urgent need to develop novel antifungal agents with… read more here.
Keywords: sporothrix globosa; novel mitochondrial; effects novel; phosundoxin ... See more keywords
IL-18 favors Th2 responses in sporotrichosis caused by Sporothrix globosa, prolonging the course of the disease
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0013170
Abstract: Background Sporotrichosis is a subcutaneous mycosis caused by members of the genus Sporothrix, among which Sporothrix globosa (S. globosa) is the predominant etiological agent in Asia. T cell immunity plays crucial roles in fungal infections,… read more here.
Keywords: disease; sporotrichosis; sporothrix globosa; globosa ... See more keywords
Biological and Clinical Attributes of Sporothrix globosa, a Causative Agent of Sporotrichosis
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DOI: 10.2147/idr.s362099
Abstract: Abstract Sporotrichosis is an important subcutaneous mycosis with high prevalence and threat to human and animal health worldwide. Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa are the main etiological agents of this disease; and even… read more here.
Keywords: sporotrichosis; biological clinical; agent; sporothrix globosa ... See more keywords
Antifungal Activity of ToAP2D Peptide Against Sporothrix globosa
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.761518
Abstract: Improving clinical efficacy and reducing treatment time have been the focus of sporotrichosis therapy. Antimicrobial peptides ToAP2A, ToAP2C, and ToAP2D were synthesized on the basis of ToAP2 (AP02759), a peptide derived from the antimicrobial peptide… read more here.
Keywords: sporothrix globosa; activity toap2d; peptide; toap2d ... See more keywords
Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.570888
Abstract: Sporotrichosis is a subcutaneous mycotic infection, and Sporothrix globosa is one of the causative agents with a worldwide distribution, notably in Asia. However, the immune profile in human sporotrichosis caused by S. globosa still remains… read more here.
Keywords: th2 tregs; sporotrichosis; sporotrichosis caused; cell ... See more keywords