Physiological functions of SPP/SPPL intramembrane proteases
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03470-6
Abstract: Intramembrane proteolysis describes the cleavage of substrate proteins within their hydrophobic transmembrane segments. Several families of intramembrane proteases have been identified including the aspartyl proteases Signal peptide peptidase (SPP) and its homologues, the SPP-like (SPPL)… read more here.
Keywords: intramembrane proteases; physiological functions; functions spp; sppl intramembrane ... See more keywords
Signaling Functions of Intramembrane Aspartyl-Proteases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2020.591787
Abstract: Intramembrane proteolysis is more than a mechanism to “clean” the membranes from proteins no longer needed. By non-reversibly modifying transmembrane proteins, intramembrane cleaving proteases hold key roles in multiple signaling pathways and often distinguish physiological… read more here.
Keywords: signaling functions; aspartyl proteases; intramembrane cleaving; spp sppl ... See more keywords