SPP1 promotes radiation resistance through JAK2/STAT3 pathway in esophageal carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4840
Abstract: Therapeutic resistance to radiotherapy is one of the major obstacles in clinical practice that significantly affect the therapeutic efficiency and prognosis of human esophageal carcinoma (ESCA). Thus, it is critical to understand the molecular mechanisms… read more here.
Keywords: esophageal carcinoma; resistance; radiation resistance; spp1 ... See more keywords
The inhibition of HeLa cells proliferation through SPARCL1 mediated by SPP1
Sign Up to like & getrecommendations! Published in 2021 at "Cytotechnology"
DOI: 10.1007/s10616-020-00443-2
Abstract: Secreted protein acidic and rich in cysteines-like 1 (SPARCL1) is implicated in tumor progression and considered as a tumor suppressor. Aim of the study is to investigate the role of SPARCL1 in the regulation of… read more here.
Keywords: overexpression; hela cells; sparcl1; proliferation ... See more keywords
Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2020391
Abstract: ABSTRACT Secreted phosphoprotein 1 (SPP1) is involved in immune regulation, cell survival, and tumor progression. Studies have demonstrated that SPP1 plays an important role in certain individual tumors. However, the expression profile and oncogenic features… read more here.
Keywords: cell; spp1; immunotherapy; tumor ... See more keywords
SPP1 expression in the mouse uterus and placenta: implications for implantation
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab125
Abstract: Abstract Secreted phosphoprotein 1 (SPP1, also known as osteopontin) binds integrins to mediate cell–cell and cell–extracellular matrix communication to promote cell adhesion, migration, and differentiation. Considerable evidence links SPP1 to pregnancy in several species. Current… read more here.
Keywords: mrna protein; spp1 expression; implantation; spp1 mrna ... See more keywords
Osteopontin drives KRAS-mutant lung adenocarcinoma.
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DOI: 10.1093/carcin/bgz190
Abstract: Increased expression of osteopontin (SPP1) is associated with aggressive human lung adenocarcinoma, but its function remains unknown. Our aim was to determine the role of SPP1 in smoking-induced lung adenocarcinoma. We combined mouse models of… read more here.
Keywords: lung adenocarcinoma; osteopontin drives; spp1; lung ... See more keywords
DOP029 SPP1 in colitis-associated colon cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0068
Abstract: Colitis-associated carcinoma (CAC) is a major complication that arises in patients with a long-standing ulcerative colitis (UC) and Crohn’s disease (CD). Albeit numerous studies report mutational landscape of CAC, its transcriptomic landscape is poorly understood.… read more here.
Keywords: immunology; cac; expression; gene ... See more keywords
TMIC-42. CONQUERING SPP1+ MYELOID-DRIVEN RESISTANCE OF GLIOBLASTOMA TO IL13RA2-TARGETED CAR T CELL THERAPY
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.1220
Abstract: In the evolving landscape of glioblastoma (GBM) therapy, the recent proliferation of clinical trials exploring chimeric antigen receptor (CAR) T cell interventions has garnered attention, although their therapeutic efficacy remains limited. Despite recent progress in… read more here.
Keywords: resistance; therapy; car cell; cell ... See more keywords
P11.15.B TUMOUR-SECRETED PHOSPHOPROTEIN 1 (SPP1) VIA ACTIVATION OF MICROGLIA CONTRIBUTES TO THE FORMATION OF THE BREAST AND LUNG CANCER BRAIN METASTASES
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf193.354
Abstract: Brain metastases (BrMets) occur in 20%-40% of patients with breast and lung cancers and contribute significantly to morbidity and/or mortality. The molecular mechanisms that drive and permit the progression of metastasis in the brain are… read more here.
Keywords: cancer; brain; microglia; spp1 ... See more keywords
Biliary YB-1/GLI2 axis facilitates ductular reaction and promotes hepatic stellate cell activation via SPP1/Integrin αvβ1 signaling during liver fibrogenesis.
Sign Up to like & getrecommendations! Published in 2025 at "Hepatology"
DOI: 10.1097/hep.0000000000001458
Abstract: BACKGROUND AIMS Emerging evidence suggests that ductular reactive cells (DRCs)-mediated ductular reaction (DR) accelerates the activation of hepatic stellate cells (HSCs) and contributes to liver fibrogenesis. Previous studies implicated Y-box binding protein 1 (YB-1) in… read more here.
Keywords: integrin; activation; gli2; gli2 axis ... See more keywords
Secreted Phosphoprotein-1 Mediates Muscle Resident Schwann Cell Dynamics and NMJ Regeneration Post Nerve Injury
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1965
Abstract: The maintenance of neuromuscular junctions (NMJs) is crucial for combating degenerative neuromuscular diseases. Maintenance of the NMJ involves turnover and regeneration with these processes dependant on the activation of Schwann cells by specific molecular cues… read more here.
Keywords: physiology; muscle; nerve; spp1 ... See more keywords
SPP1 Promotes Enzalutamide Resistance and Epithelial-Mesenchymal-Transition Activation in Castration-Resistant Prostate Cancer via PI3K/AKT and ERK1/2 Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/5806602
Abstract: The bottleneck arising from castration-resistant prostate cancer (CRPC) treatment is its high metastasis potential and antiandrogen drug resistance, which severely affects survival time of prostate cancer (PCa) patients. Secreted phosphoprotein 1 (SPP1) is a cardinal… read more here.
Keywords: prostate; prostate cancer; resistance; castration resistant ... See more keywords