Abstract 5855: Spatial transcriptomics deciphers the cellular society of advanced colorectal cancer
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DOI: 10.1158/1538-7445.am2023-5855
Abstract: Introduction: In recent years, single-cell RNA sequencing (scRNA-seq) and high-dimensional spatial transcriptomics (ST-seq) have contributed significantly to our understanding of the tumor microenvironment (TME) in many cancers. This is essential for understanding the tumor-stromal crosstalk.… read more here.
Keywords: spp1 macrophages; transcriptomics deciphers; spatial transcriptomics; tumor ... See more keywords
CD11c+ macrophages are proangiogenic and necessary for experimental choroidal neovascularization
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DOI: 10.1172/jci.insight.168142
Abstract: Patients with neovascular AMD (nAMD) suffer vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Macrophages are found in CNV lesions from patients with nAMD. Additionally, Ccr2–/– mice, which lack classical monocyte–derived macrophages, show reduced… read more here.
Keywords: cd11c; spp1 macrophages; choroidal neovascularization; cd11c macrophages ... See more keywords