Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane
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DOI: 10.1021/acsinfecdis.9b00159
Abstract: Therapeutics targeting Gram-negative bacteria have the challenge of overcoming a formidable outer membrane (OM) barrier. Here, we characterize the action of SPR741, a novel polymyxin B (PMB) analog... read more here.
Keywords: outer membrane; gram negative; negative bacteria; spr741 ... See more keywords
Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741
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DOI: 10.1128/aac.00200-17
Abstract: ABSTRACT Novel approaches for the treatment of multidrug-resistant Gram-negative bacterial infections are urgently required. One approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented… read more here.
Keywords: spr741; gram negative; spectrum activity; potentiation ... See more keywords