Fertility and early embryonic development toxicity and toxicokinetic study of KFP‐H008 in Sprague–Dawley rats
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DOI: 10.1002/bdr2.2002
Abstract: The novel potassium competitive acid blocker, KFP‐H008, developed to overcome the shortcomings of proton pump inhibitors. In this study, KFP‐H008 was administered by oral gavage at doses of 0 (control), 15, 45, and 150 mg/kg to… read more here.
Keywords: sprague dawley; dawley rats; toxicokinetic study; study kfp ... See more keywords
Memory deficits in Sprague Dawley rats with spontaneous ventriculomegaly
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1711
Abstract: Spontaneous ventriculomegaly has been observed in rats that were presumed normal. Because the external phenotype of these animals is unremarkable, they can be inadvertently included in behavioral experiments, despite the considerable enlargement of the ventricular… read more here.
Keywords: spontaneous ventriculomegaly; deficits sprague; memory deficits; rats spontaneous ... See more keywords
General toxicity and genotoxicity of altertoxin I: A novel 28‐day multiendpoint assessment in male Sprague–Dawley rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4297
Abstract: The mycotoxin altertoxin I (ATX‐I) is one of secondary metabolites produced by Alternaria fungi and is frequently detected as food and feed contaminants. Little is known about the genotoxicity of the ATX‐I. In order to… read more here.
Keywords: sprague dawley; novel day; day multiendpoint; male sprague ... See more keywords
Forced running-induced rhabdomyolysis in the Sprague-Dawley rat: towards a rodent model of capture myopathy.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary research communications"
DOI: 10.1007/s11259-021-09840-0
Abstract: Capture myopathy (CM) is a metabolic disease associated with mortality in mass boma captured (MBC) wildlife. The condition is induced by the forced pursuit, capturing, and restraint of wild animals, although its causal biology remains to… read more here.
Keywords: rhabdomyolysis sprague; capture myopathy; rhabdomyolysis; model ... See more keywords
Co-supplementation of Zinc and Calcium Suppresses Bio-absorption of Lead in Sprague Dawley Rats.
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DOI: 10.1007/s12011-022-03233-3
Abstract: Lead (Pb) is a widespread environmental toxicant and its toxicity causes huge health impacts. The present study was conducted to examine the protective role of zinc (Zn) and calcium (Ca) supplements against bio-absorption of Pb in… read more here.
Keywords: bio absorption; zinc calcium; liver kidney; standard diet ... See more keywords
Bilateral Olfactory Mucosa Damage Induces the Disappearance of Olfactory Glomerulus and Reduces the Expression of Extrasynaptic α5GABAARs in the Hippocampus in Early Postnatal Sprague Dawley Rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9893-3
Abstract: Chloroform-induced olfactory mucosal degeneration has been reported in adult rats following gavage. We used fixed-point chloroform infusions on different postnatal days (PNDs) to investigate the effects of early olfactory bilateral deprivation on the main olfactory… read more here.
Keywords: olfactory; disappearance; dawley rats; chloroform ... See more keywords
A cafeteria diet alters the decision making strategy and metabolic markers in Sprague-Dawley male rats
Sign Up to like & getrecommendations! Published in 2017 at "Applied Animal Behaviour Science"
DOI: 10.1016/j.applanim.2017.10.012
Abstract: Abstract Consumption of diets rich in refined sugar and saturated fat has been linked with development of mild cognitive impairment and dementia in humans. Most cognitive paradigms used in biomedical research to investigate the relationship… read more here.
Keywords: decision; male rats; cafeteria diet; decision making ... See more keywords
High-fructose diet initiated during adolescence does not affect basolateral amygdala excitability or affective-like behavior in Sprague Dawley rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.02.042
Abstract: &NA; Patients with type‐2 diabetes, obesity, and metabolic syndrome have a significantly increased risk of developing depression. Dysregulated metabolism may contribute to the etiology of depression by affecting neuronal activity in key limbic areas. The… read more here.
Keywords: like behavior; sprague dawley; dawley rats; excitability ... See more keywords
Effects of subanesthetic intravenous ketamine infusion on neuroplasticity-related proteins in the prefrontal cortex, amygdala, and hippocampus of Sprague-Dawley rats
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DOI: 10.1016/j.ibror.2019.01.006
Abstract: Ketamine, a multimodal dissociative anesthetic, is a powerful analgesic administered following trauma due to its hemodynamic and respiratory stability. However, ketamine can cause hallucination and dissociation which may adversely impact traumatic memory after an injury.… read more here.
Keywords: ketamine infusion; hippocampus; infusion; sprague dawley ... See more keywords
High-dose etoposide formulations do not saturate intestinal P-glycoprotein: Development, stability, and pharmacokinetics in Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119399
Abstract: It has been suggested that oral absorption of low-permeable P-glycoprotein (P-gp) substrates can be increased through saturation of P-gp. For BCS class IV drug substances, saturating P-gp is challenging due to low aqueous solubility. The… read more here.
Keywords: dawley rats; formulation; solubility; glycoprotein ... See more keywords
Mutagenicity and genotoxicity effects of Verbena officinalis leaves extract in Sprague-Dawley Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.02.007
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Traditionally, Verbena officinalis L. has been used for reproductive and gynaecological purposes. However, the mutagenicity and genotoxicity of V. officinalis have not been extensively investigated. AIM OF THE STUDY To assess the in… read more here.
Keywords: verbena officinalis; genotoxicity; officinalis leaves; mutagenicity genotoxicity ... See more keywords