Terminal spreading depolarization and electrical silence in death of human cerebral cortex
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25147
Abstract: Restoring the circulation is the primary goal in emergency treatment of cerebral ischemia. However, better understanding of how the brain responds to energy depletion could help predict the time available for resuscitation until irreversible damage… read more here.
Keywords: depolarization electrical; terminal spreading; silence death; spreading depolarization ... See more keywords
Cilostazol decreases duration of spreading depolarization and spreading ischemia after aneurysmal subarachnoid hemorrhage
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25361
Abstract: Traditionally, angiographic vasospasm (aVS) has been thought to cause delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). However, successful treatment of aVS alone does not result in improved neurological outcome. Therefore, there may be… read more here.
Keywords: aneurysmal subarachnoid; spreading depolarization; ischemia; subarachnoid hemorrhage ... See more keywords
Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury
Sign Up to like & getrecommendations! Published in 2019 at "GeroScience"
DOI: 10.1007/s11357-019-00142-7
Abstract: Spreading depolarization is observed as a large negative shift of the direct current potential, swelling of neuronal somas, and dendritic beading in the brain’s gray matter and represents a state of a potentially reversible mass… read more here.
Keywords: depolarization; migraine aura; spreading depolarization; spreading depression ... See more keywords
Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.07.026
Abstract: Recurrent spreading depolarizations occur in the cerebral cortex from minutes up to weeks following acute brain injury. Clinical evidence suggests that the immediate reduction of cerebral blood flow in response to spreading depolarization importantly contributes… read more here.
Keywords: spreading depolarization; potassium; large conductance; response spreading ... See more keywords
Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.09.027
Abstract: ABSTRACT Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures that only occurs under pathological conditions. In the present paper, we summarize the evidence from several decades of research that SD and… read more here.
Keywords: gray matter; spreading depolarization; cytotoxic edema; edema ... See more keywords
Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01284-4
Abstract: Spreading depolarizations (SDs) occur spontaneously in the cerebral cortex of subarachnoid hemorrhage, stroke or traumatic brain injury patients. Accumulating evidence prove that SDs exacerbate focal ischemic injury by converting zones of the viable but non-functional… read more here.
Keywords: tissue acidosis; depolarization remarkably; spreading depolarization; tissue ... See more keywords
Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07119-6
Abstract: Spreading depolarization (SD) is a slow propagating wave of strong depolarization of neural cells, implicated in several neuropathological conditions. The breakdown of brain homeostasis promotes significant hemodynamic and metabolic alterations, which impacts on neuronal function.… read more here.
Keywords: multimodal approach; spreading depolarization; lactate glucose; microbiosensor ... See more keywords
Chill coma in the locust, Locusta migratoria, is initiated by spreading depolarization in the central nervous system
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10586-6
Abstract: The ability of chill-sensitive insects to function at low temperatures limits their geographic ranges. They have species-specific temperatures below which movements become uncoordinated prior to entering a reversible state of neuromuscular paralysis. In spite of… read more here.
Keywords: chill coma; spreading depolarization; nervous system; central nervous ... See more keywords
Spreading depolarization occurs in repeating, recognizable, patient-specific patterns after human brain injury
Sign Up to like & getrecommendations! Published in 2021 at "Brain Injury"
DOI: 10.1080/02699052.2020.1861480
Abstract: ABSTRACT Background and Objective: Electrocorticographic (ECoG) measurement of spreading depolarization (SD) has led to significant advances in understanding of injury progression in neuro ICU patients. However, SD can be difficult to recognize in ECoG regions… read more here.
Keywords: patient specific; spreading depolarization; brain injury; brain ... See more keywords
A new direction for spreading depolarization: Investigation in the fly brain
Sign Up to like & getrecommendations! Published in 2017 at "Channels"
DOI: 10.1080/19336950.2016.1239898
Abstract: Spreading depolarization (SD) is a complex neural phenomenon which we still do not fully understand. Fifty years after its initial discovery by Le~ao, evidence suggested that SD may not occur in humans, however it is… read more here.
Keywords: spreading depolarization; new direction; model; fly brain ... See more keywords
Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab141
Abstract: Abstract Spreading depolarization is a slowly propagating wave of massive cellular depolarization associated with acute brain injury and migraine aura. Genetic studies link depolarizing molecular defects in Ca2+ flux, Na+ current in interneurons, and glial… read more here.
Keywords: spreading depolarization; depolarization; cortical spreading; kcnq2 kv7 ... See more keywords