Spreading Depolarizations and Neurological Deterioration in Patients with Subdural Hematoma: Putting a Name to a Face?
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DOI: 10.1007/s12028-021-01364-4
Abstract: Chronic subdural hematomas (cSDHs) are an increasingly common disease encountered by neurointensivists [1]. Episodic neurologic symptoms have been well described in patients with cSDH [2, 3], and although some syndromes are caused by focal seizures… read more here.
Keywords: deterioration; patients csdh; probable sds; cohort ... See more keywords
Determinants of Optogenetic Cortical Spreading Depolarizations
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DOI: 10.1093/cercor/bhy021
Abstract: &NA; Cortical spreading depolarization (SD) is the electrophysiological event underlying migraine aura, and a critical contributor to secondary damage after brain injury. Experimental models of SD have been used for decades in migraine and brain… read more here.
Keywords: determinants optogenetic; spreading depolarizations; injury; cortical spreading ... See more keywords
Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations
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DOI: 10.1161/strokeaha.120.029618
Abstract: Supplemental Digital Content is available in the text. Background and Purpose: Spreading depolarizations (SDs) are recurrent and ostensibly spontaneous depolarization waves that may contribute to infarct progression after stroke. Somatosensory activation of the metastable peri-infarct… read more here.
Keywords: hot zones; activation; spreading depolarizations; functional activation ... See more keywords
Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome
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DOI: 10.1161/strokeaha.122.041351
Abstract: Background: Spreading depolarizations (SDs) are believed to contribute to injury progression and worsen outcomes in focal cerebral ischemia because exogenously induced SDs have been associated with enlarged infarct volumes. However, previous studies used highly invasive… read more here.
Keywords: worsen acute; depolarizations worsen; spreading depolarizations; infarct volumes ... See more keywords