Activation of pial and dural macrophages and dendritic cells by cortical spreading depression
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25169
Abstract: Cortical spreading depression (CSD) has long been implicated in migraine attacks with aura. The process by which CSD, a cortical event that occurs within the blood–brain barrier (BBB), results in nociceptor activation outside the BBB… read more here.
Keywords: activation pial; cortical spreading; spreading depression; bbb ... See more keywords
Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury
Sign Up to like & getrecommendations! Published in 2019 at "GeroScience"
DOI: 10.1007/s11357-019-00142-7
Abstract: Spreading depolarization is observed as a large negative shift of the direct current potential, swelling of neuronal somas, and dendritic beading in the brain’s gray matter and represents a state of a potentially reversible mass… read more here.
Keywords: depolarization; migraine aura; spreading depolarization; spreading depression ... See more keywords
Macro scale modelling of cortical spreading depression and the role of astrocytic gap junctions.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.09.006
Abstract: Neuronal activity evokes a localised increase in cerebral blood flow in a response known as neurovascular coupling (NVC), achieved through communication between a group of cells known as a neurovascular unit (NVU). Dysfunctional NVC can… read more here.
Keywords: gap; gap junctions; spreading depression; model ... See more keywords
The effects of cerebral curvature on cortical spreading depression.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.04.006
Abstract: Neuronal activity evokes a localised increase in cerebral blood flow through neurovascular coupling (NVC), a communication system between a group of cells known as a neurovascular unit (NVU). Dysfunctional NVC can lead to pathologies such… read more here.
Keywords: wave segments; spreading depression; diffusion rate; cortical spreading ... See more keywords
Spreading depression as an innate antiseizure mechanism
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22464-x
Abstract: Spreading depression (SD) is an intense and prolonged depolarization in the central nervous systems from insect to man. It is implicated in neurological disorders such as migraine and brain injury. Here, using an in vivo… read more here.
Keywords: seizure; depression innate; spreading depression; innate antiseizure ... See more keywords
The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36330-2
Abstract: The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates… read more here.
Keywords: substance; spreading depression; depression csd; csds ... See more keywords
Vagus nerve stimulation inhibits cortical spreading depression exclusively via central mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001856
Abstract: Experimental and clinical data strongly support vagus nerve stimulation (VNS) as a novel treatment in migraine. VNS acutely suppresses cortical spreading depression (CSD) susceptibility, an experimental model that has been used to screen for migraine… read more here.
Keywords: spreading depression; nerve stimulation; stimulation; vagus nerve ... See more keywords
The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization
Sign Up to like & getrecommendations! Published in 2018 at "Pain Reports"
DOI: 10.1097/pr9.0000000000000632
Abstract: Introduction: Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents. One putative mechanism underlying this afferent response involves an acute excitation of meningeal… read more here.
Keywords: spreading depression; cgrp; activation; meningeal ... See more keywords
Transient loss of interhemispheric functional connectivity following unilateral cortical spreading depression in awake rats
Sign Up to like & getrecommendations! Published in 2020 at "Cephalalgia"
DOI: 10.1177/0333102420970172
Abstract: Objective Growing evidence shows a critical role of network disturbances in the pathogenesis of migraine. Unilateral pattern of neurological symptoms of aura suggests disruption of interhemispheric interactions during the early phase of a migraine attack.… read more here.
Keywords: unilateral cortical; cortical spreading; spreading depression; functional connectivity ... See more keywords
Effects of garlic extract on spreading depression: In vitro and in vivo investigations
Sign Up to like & getrecommendations! Published in 2017 at "Nutritional Neuroscience"
DOI: 10.1179/1476830514y.0000000148
Abstract: Objectives: The potential use of garlic for prevention and treatment of different types of headaches has been suggested by several medieval literatures. Cortical spreading depression (CSD), a propagating wave of neuroglial depolarization, was established as… read more here.
Keywords: garlic extract; spreading depression; effects garlic; csd ... See more keywords
Validating a computational framework for ionic electrodiffusion with cortical spreading depression as a case study.
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0408-21.2022
Abstract: Cortical spreading depression (CSD) is a wave of pronounced depolarization of brain tissue accompanied by substantial shifts in ionic concentrations and cellular swelling. Here, we validate a computational framework for modelling electrical potentials, ionic movement,… read more here.
Keywords: spreading depression; cortical spreading; csd; framework ... See more keywords