SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB in Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2426464122
Abstract: Significance Signal peptidases are essential for protein secretion in all bacteria. In Staphylococcus aureus, the signal peptidase SpsB also cleaves lipoteichoic acid synthase (LtaS), which assembles the essential surface polymer lipoteichoic acid (LTA). Whether cleavage… read more here.
Keywords: peptidase spsb; signal peptidase; staphylococcus aureus; spsb ... See more keywords
Signal peptidase SpsB coordinates staphylococcal cell cycle, surface protein septal trafficking, and LTA synthesis
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DOI: 10.1128/mbio.02673-24
Abstract: ABSTRACT Cell wall-anchored surface proteins of Gram-positive bacteria, harboring a highly conserved YSIRK/G-S signal peptide (SPYSIRK+), are deposited at cell division septum and anchored to septal peptidoglycan. The mechanisms supporting YSIRK protein septal trafficking remain… read more here.
Keywords: cell cycle; septal trafficking; cell; lta synthesis ... See more keywords