SQLE facilitates the pancreatic cancer progression via the lncRNA‐TTN‐AS1/miR‐133b/SQLE axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17347
Abstract: Studies have shown that SQLE is highly expressed in a variety of tumours and promotes tumour progression. However, the role of SQLE in pancreatic cancer (PC) has not been reported. Here, we aim to study… read more here.
Keywords: ttn as1; mir 133b; lncrna ttn; sqle ... See more keywords
Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
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DOI: 10.1136/gutjnl-2021-325851
Abstract: OBJECTIVE Aberrant lipid metabolism is a hallmark of colorectal cancer (CRC). Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is upregulated in CRC. Here, we aim to determine oncogenic function of SQLE and its… read more here.
Keywords: sqle mice; mice; sqle; cell proliferation ... See more keywords
Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy.
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DOI: 10.1158/0008-5472.can-21-2229
Abstract: Over 50% of all cancer patients are treated with radiation therapy (RT). However, RT is often insufficient as a monotherapy and requires a non-toxic radiosensitizer. Squalene epoxidase (SQLE) controls cholesterol biosynthesis by converting squalene to… read more here.
Keywords: squalene epoxidase; inhibition; sqle; response ... See more keywords
Squalene epoxidase metabolic dependency is a targetable vulnerability in castration-resistant prostate cancer.
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DOI: 10.1158/0008-5472.can-21-3822
Abstract: Considering the dismal prognosis of castration-resistant prostate cancer (CRPC), it is critical to identify novel therapeutic targets in this disease. Malignant cells have metabolic dependencies distinct from their healthy counterparts, resulting in therapeutic vulnerabilities. While… read more here.
Keywords: prostate cancer; resistant prostate; castration resistant; sqle ... See more keywords
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma
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DOI: 10.3389/fimmu.2022.864244
Abstract: Background Pancreatic adenocarcinoma (PAAD) is a treatment-refractory cancer with poor prognosis. Accumulating evidence suggests that squalene epoxidase (SQLE) plays a pivotal role in the development and progression of several cancer types in humans. However, the… read more here.
Keywords: cholesterol metabolism; immunotherapy; tumor immune; sqle ... See more keywords
Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer
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DOI: 10.3892/ol.2021.12520
Abstract: Differentially expressed genes (DEGs) have been previously identified using massive parallel RNA sequencing in matched normal, breast cancer (BC) and nodal metastatic tissues. Squalene epoxidase (SQLE), one of these DEGs, is a key enzyme in… read more here.
Keywords: high sqle; breast; sqle expression; expression associated ... See more keywords
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma
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DOI: 10.7150/ijbs.68216
Abstract: Recently, increasing attention has been paid to the role of Squalene epoxidase (SQLE) in several types of cancers. However, its functional role in tumor progression of head and neck squamous cell carcinoma (HNSCC) is still… read more here.
Keywords: cell carcinoma; head neck; squamous cell; hnscc ... See more keywords