Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
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DOI: 10.1136/gutjnl-2021-325851
Abstract: OBJECTIVE Aberrant lipid metabolism is a hallmark of colorectal cancer (CRC). Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is upregulated in CRC. Here, we aim to determine oncogenic function of SQLE and its… read more here.
Keywords: sqle mice; mice; sqle; cell proliferation ... See more keywords