The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.03.030
Abstract: Summary Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia. The pathogenic mechanism that contributes… read more here.
Keywords: sqstm1 p62; function; mitochondrial function; role ... See more keywords
HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2016.1248018
Abstract: ABSTRACT Proteostasis is important for protecting cells from harmful proteins and is mainly controlled by the HSF1 (heat shock transcription factor 1) stress response pathway. This pathway facilitates protein refolding by molecular chaperones; however, it… read more here.
Keywords: response pathway; proteostasis; hsf1; stress response ... See more keywords
Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1415190
Abstract: ABSTRACT In macroautophagy/autophagy, cargoes are collected by specific receptors, such as SQSTM1/p62 (sequestosome 1), and delivered to phagophores for lysosomal degradation. To date, little is known about how cells modulate SQSTM1 activity and autophagosome biogenesis… read more here.
Keywords: sqstm1; rule pathway; end rule; sqstm1 p62 ... See more keywords
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1659612
Abstract: ABSTRACT Defective macroautophagy/autophagy and mitochondrial dysfunction are known to stimulate senescence. The mitochondrial regulator PPARGC1A (peroxisome proliferator activated receptor gamma, coactivator 1 alpha) regulates mitochondrial biogenesis, reducing senescence of vascular smooth muscle cells (VSMCs); however,… read more here.
Keywords: senescence; ppargc1a; autophagy; smooth muscle ... See more keywords
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1686729
Abstract: TARDBP/TDP-43 (TAR DNA binding protein) proteinopathies are a common feature in a variety of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer disease (AD). However, the molecular mechanisms underlying TARDBP-induced… read more here.
Keywords: tardbp tdp; ptk2 fak; tardbp; kinase ... See more keywords
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1712108
Abstract: ABSTRACT Lipotoxicity, induced by saturated fatty acid (SFA)-mediated cell death, plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The KEAP1 (kelch like ECH associated protein 1)-NFE2L2/NRF2 (nuclear factor, erythroid 2… read more here.
Keywords: sqstm1 p62; lipotoxicity; kinase; nfe2l2 nrf2 ... See more keywords
A dominant-negative regulatory mechanism of SQSTM1 droplets-based autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2029672
Abstract: ABSTRACT SQSTM1/p62 is an autophagy receptor, forming droplets to sequester intracellular polyubiquitinated cargo and mediate its delivery for autophagic clearance. SQSTM1 droplets can function as platforms to allow the formation of autophagosomes at their surfaces.… read more here.
Keywords: cleavage; sqstm1 droplets; sqstm1; dominant negative ... See more keywords
Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2054240
Abstract: ABSTRACT The N-degron pathway is a proteolytic system in which the N-terminal degrons (N-degrons) of proteins, such as arginine (Nt-Arg), induce the degradation of proteins and subcellular organelles via the ubiquitin-proteasome system (UPS) or macroautophagy/autophagy-lysosome… read more here.
Keywords: chemical modulation; xenophagy; sqstm1 p62; broad range ... See more keywords
SQSTM1, lipid droplets and current state of their lipophagy affairs
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2094606
Abstract: ABSTRACT SQSTM1/p62 (sequestosome 1) is a well-established indicator of macroautophagic/autophagic flux. It was initially characterized as the ubiquitin-binding autophagic receptor in aggrephagy, the selective autophagy of ubiquitinated protein aggregates. Recently, several studies correlated its levels… read more here.
Keywords: lipid droplets; lipophagy; selective autophagy; sqstm1 ... See more keywords
DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3-SQSTM1-STING pathway
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2044667
Abstract: ABSTRACT DNA damage-inducible transcript 3 (DDIT3), a transcription factor, is typically involved in virus replication control. We are the first to report that DDIT3 promotes the replication of bovine viral diarrhea virus, an RNA virus,… read more here.
Keywords: promote bovine; replication; ddit3; immune response ... See more keywords
Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aat6903
Abstract: A p62 fragment generated by caspase-8 regulates responses to nutrient availability, rather than autophagy. Cleaving a different function for p62 The scaffold protein p62 has a critical role in autophagy, the regulated degradation of proteins… read more here.
Keywords: caspase; p62trm; regulated proteolysis; p62 ... See more keywords