Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201800769
Abstract: Malformin A1 (MA1) is a fungus‐produced cyclic pentapeptide. MA1 exhibits teratogenicity to plants, fibrinolysis‐enhancing activity, and cytotoxicity to mammalian cells. To clarify the cytotoxic mechanism of MA1, we screened for the genes involved in the cytotoxicity… read more here.
Keywords: crispr cas9; ma1; cytotoxicity; squalene epoxidase ... See more keywords
Squalene epoxidase as a promising metabolic target in cancer treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.034
Abstract: Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. In the present review, we focus on squalene epoxidase (SE), one of the two rate-limiting enzymes in cholesterol synthesis, retracing its… read more here.
Keywords: squalene epoxidase; target; target cancer; cancer treatment ... See more keywords
Mechanism of streptomyces albidoflavus STV1572a derived 1-heneicosanol as an inhibitor against squalene epoxidase of Trichophyton mentagrophytes.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.104853
Abstract: An increase in incidences of tinea infections paves the way to discover the novel antifungal drugs from unexplored natural resources. The quality of life in patients with tinea infection may be affected by different factors,… read more here.
Keywords: study; mechanism; squalene epoxidase; albidoflavus stv1572a ... See more keywords
Squalene epoxidase facilitates cervical cancer progression by modulating tumor protein p53 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15576
Abstract: The mortality of cervical cancer (CC) is quite high and advanced CC is hard to cure. Accordingly, to find the mechanism of CC progression at molecular level is imminent. read more here.
Keywords: cervical cancer; squalene epoxidase; progression; facilitates cervical ... See more keywords
Report of terbinafine resistant Trichophyton spp. in Italy: Clinical presentations, molecular identification, antifungal susceptibility testing and mutations in the squalene epoxidase gene.
Sign Up to like & getrecommendations! Published in 2023 at "Mycoses"
DOI: 10.1111/myc.13597
Abstract: BACKGROUND Numerous reports of resistance to terbinafine in Trichophyton spp. from all over the world are arousing justified attention and concern. Point mutations in the gene that encodes the squalene epoxidase (SQLE) enzyme are responsible… read more here.
Keywords: squalene epoxidase; trichophyton; terbinafine; trichophyton spp ... See more keywords
Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00056-21
Abstract: During the past decade, a prolonged and serious outbreak of dermatophytosis due to a terbinafine-resistant novel species in the Trichophyton mentagrophytes-T. interdigitale complex has been ongoing in India, and it has spread to several European… read more here.
Keywords: mentagrophytes species; trichophyton mentagrophytes; gene; antifungal susceptibility ... See more keywords
Checkerboard Analysis To Evaluate Synergistic Combinations of Existing Antifungal Drugs and Propylene Glycol Monocaprylate in Isolates from Recalcitrant Tinea Corporis and Cruris Patients Harboring Squalene Epoxidase Gene Mutation
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00321-21
Abstract: Recalcitrant dermatophytic infections of the glabrous skin (tinea corporis/cruris/faciei) pose a huge challenge to health care systems. Combinations of oral and topical drugs may potentially improve cure rates, but the same has never been objectively… read more here.
Keywords: tinea corporis; recalcitrant tinea; corporis cruris; synergistic combinations ... See more keywords
Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine Resistance
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02522-17
Abstract: ABSTRACT Dermatophytosis, the commonest superficial fungal infection, has gained recent attention due to its change of epidemiology and treatment failures. Despite the availability of several agents effective against dermatophytes, the incidences of chronic infection, reinfection,… read more here.
Keywords: mutation; rubrum; squalene epoxidase; trichophyton ... See more keywords
Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2229
Abstract: Over 50% of all cancer patients are treated with radiation therapy (RT). However, RT is often insufficient as a monotherapy and requires a non-toxic radiosensitizer. Squalene epoxidase (SQLE) controls cholesterol biosynthesis by converting squalene to… read more here.
Keywords: squalene epoxidase; inhibition; sqle; response ... See more keywords
Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201612
Abstract: The authors describe the ER-associated degradation of Erg1 under increased membrane lipid saturation and show its importance in balancing sterol levels for membrane integrity in budding yeast. A fluid membrane containing a mix of unsaturated… read more here.
Keywords: squalene epoxidase; sterol homeostasis; saturation; lipid saturation ... See more keywords