A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1915923117
Abstract: Significance Cholesterol is an essential component of cell membranes and a precursor for steroid hormones and bile acids. Squalene monooxygenase (SM) is a rate-limiting enzyme in the cholesterol biosynthetic pathway and has been demonstrated to… read more here.
Keywords: cholesterol synthesis; squalene monooxygenase; cholesterol; squalene ... See more keywords
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.18.504470
Abstract: Cholesterol synthesis is both energy- and oxygen-intensive, yet relatively little is known of the regulatory effects of hypoxia on pathway enzymes. We previously showed that the rate-limiting and first oxygen-requiring enzyme of the committed cholesterol… read more here.
Keywords: squalene monooxygenase; cholesterol; cholesterol synthesis;