AdoMet triggers apoptosis in head and neck squamous cancer by inducing ER stress and potentiates cell sensitivity to cisplatin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28000
Abstract: S‐Adenosyl‐l‐methionine (AdoMet) is a naturally and widely occurring sulfonium compound that plays a primary role in cell metabolism and acts as the principal methyl donor in many methylation reactions. AdoMet also exhibits antiproliferative and proapoptotic… read more here.
Keywords: apoptosis; cisplatin; squamous cancer; stress ... See more keywords
Lapatinib in combination with paclitaxel plays synergistic antitumor effects on esophageal squamous cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3627-3
Abstract: PurposePaclitaxel-based chemoradiotherapy was proven to be efficacious in treating patients with advanced esophageal cancer. However, the toxicity and the development of resistance limited its anticancer efficiency. The present study was to evaluate the antitumor effects… read more here.
Keywords: combination; squamous cancer; antitumor; cancer ... See more keywords
A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27055-4
Abstract: Amplification and overexpression of the SOX2 oncogene represent a hallmark of squamous cancers originating from diverse tissue types. Here, we find that squamous cancers selectively amplify a 3' noncoding region together with SOX2, which harbors… read more here.
Keywords: expression; predominant enhancer; squamous cancer; enhancer ... See more keywords
Abstract 3610: Prenylated PALM2 promotes the migration of esophageal squamous cancer cells through activating ezrin
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3610
Abstract: Proteins containing a CAAX motif at the C-terminus can occur prenylation modification and regulate the localization and activity of a series of key regulatory proteins, including RAS superfamily members, heterotrimeric G proteins, nuclear lamina protein,… read more here.
Keywords: palm2; cancer; ezrin; esophageal squamous ... See more keywords
Esophageal Squamous Cancer from 4NQO-Induced Mice Model: CNV Alterations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214304
Abstract: Squamous esophageal carcinoma is a common pathological type of esophageal carcinoma around the world. The prognosis of esophageal carcinoma is usually poor and diagnosed at late stages. Recently, research suggested that genomic instability occurred in… read more here.
Keywords: esophageal carcinoma; esophageal squamous; mice; cancer ... See more keywords