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Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.08.034
Abstract: Abstract Enantiomerically pure α-chiral amines, have been commonly utilized as resolving agents and chiral auxiliaries and are currently found in 40% of active pharmaceutical ingredients. Hence, development of highly stereoselective metal-free protocols regarding atom-economy and…
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Keywords:
squaramide catalyzed;
carbon;
amine synthesis;
chiral amine ... See more keywords
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Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00074
Abstract: Herein is disclosed an efficient enantio- and diastereoselective spiroketalization of aromatic ketone tethered to ortho-homoformyl and enone moiety via in situ enol formation using quinine derived squaramide organocatalyst to access aromatic [6,5] spiroketals with complete…
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Keywords:
spiroketalization;
asymmetric spiroketalization;
aromatic spiroketals;
catalyzed asymmetric ... See more keywords