Squaramide catalyzed α-chiral amine synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.08.034
Abstract: Abstract Enantiomerically pure α-chiral amines, have been commonly utilized as resolving agents and chiral auxiliaries and are currently found in 40% of active pharmaceutical ingredients. Hence, development of highly stereoselective metal-free protocols regarding atom-economy and… read more here.
Keywords: squaramide catalyzed; carbon; amine synthesis; chiral amine ... See more keywords
Chiral Squaramide Catalyzed Asymmetric Spiroketalization toward Aromatic [6,5] Spiroketals.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00074
Abstract: Herein is disclosed an efficient enantio- and diastereoselective spiroketalization of aromatic ketone tethered to ortho-homoformyl and enone moiety via in situ enol formation using quinine derived squaramide organocatalyst to access aromatic [6,5] spiroketals with complete… read more here.
Keywords: spiroketalization; asymmetric spiroketalization; aromatic spiroketals; catalyzed asymmetric ... See more keywords