Digestion of Lipid-Based Formulations Not Only Mediates Changes to Absorption of Poorly Soluble Drugs Due to Differences in Solubilization But Also Reflects Changes to Thermodynamic Activity and Permeability.
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DOI: 10.1021/acs.molpharmaceut.1c00015
Abstract: The aim of this study was to evaluate the effect of lipid digestion on the permeability and absorption of orally administered saquinavir (SQV), a biopharmaceutics classification system (BCS) class IV drug, in different lipid-based formulations.… read more here.
Keywords: based formulations; lipid based; sqv; digestion ... See more keywords
Drug-transporter mediated interactions between anthelminthic and antiretroviral drugs across the Caco-2 cell monolayers
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DOI: 10.1186/s40360-017-0129-6
Abstract: BackgroundDrug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a transwell. The impact of anthelminthics on the transport… read more here.
Keywords: cell monolayers; sqv; transport; drug ... See more keywords