Circ-MKLN1/miR-377-3p/CTGF Axis Regulates the TGF-β2-induced Posterior Capsular Opacification in SRA01/04 Cells.
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DOI: 10.1080/02713683.2021.1988983
Abstract: OBJECTIVE Posterior capsular opacification (PCO) is a common postoperative ocular complication after cataract surgery. Little research focused on the regulation of circular RNAs (circRNAs) in PCO. This study was designed to investigate the function of… read more here.
Keywords: mir 377; ctgf; circ mkln1; sra01 cells ... See more keywords
LncRNA KCNQ1OT1 promotes apoptosis and oxidative stress of human lens epithelial cells through epigenetic regulation of WRN.
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DOI: 10.1080/02713683.2022.2026975
Abstract: PURPOSE Long non-coding RNA KCNQ1OT1 is fundamental to age-related cataract (ARC), whereas the underlying mechanism is still unknown. Here, we explored the possible mechanism of KCNQ1OT1 in ARC. METHODS The expression of KCNQ1OT1 in ARC… read more here.
Keywords: wrn; apoptosis oxidative; sra01 cells; oxidative stress ... See more keywords
CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract
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DOI: 10.1080/15384101.2022.2114587
Abstract: ABSTRACT Circular RNAs (circRNAs) have shown pivotal regulatory roles in multiple human ocular diseases, including age-related cataract (ARC). Here, we explored the role of circRNA mitogen-activated protein kinase kinase kinase 4 (circMAP3K4, hsa_circ_0078619) in ARC… read more here.
Keywords: sra01 cells; h2o2 induced; plcd3; cells h2o2 ... See more keywords
Paeoniflorin inhibits epithelial mesenchymal transformation and oxidative damage of lens epithelial cells in diabetic cataract via sirtuin 1 upregulation
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DOI: 10.1080/21655979.2021.2018534
Abstract: ABSTRACT Paeoniflorin (Pae) has been reported to serve an important role in complications associated with diabetes. To the best of our knowledge, the role of Pae in diabetic cataracts has not yet been reported. Human… read more here.
Keywords: sra01 cells; damage; lens epithelial; oxidative damage ... See more keywords
Role of long noncoding RNA KCNQ1 overlapping transcript 1/microRNA-124-3p/BCL-2-like 11 axis in hydrogen peroxide (H2O2)-stimulated human lens epithelial cells
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DOI: 10.1080/21655979.2022.2032966
Abstract: ABSTRACT Age-related cataract (ARC) is one of the most common causes of vision loss in aging people. This research analyzed the functions and mechanism of long noncoding RNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) in hydrogen… read more here.
Keywords: sra01 cells; mir 124; long noncoding; h2o2 stimulated ... See more keywords
EphA2 overexpression reduces H2O2-induced damage of lens epithelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2020-0414
Abstract: Abstract Age-related cataract (ARC) is a progressive lens opacification that occurs from middle to old age. Eph-receptor tyrosinekinase-type A2 (EphA2) has been reported to be associated with ARC. This work aims to investigate the molecular… read more here.
Keywords: h2o2 induced; lens epithelial; epithelial cells; sra01 cells ... See more keywords