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   Articles with "src" as a keyword



Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells.

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recommendations! Published in 2025 at "Molecular oncology"

DOI: 10.1002/1878-0261.70155

Abstract: Rearranged during transfection (RET) fusions drive subsets of non-small cell lung cancer (NSCLC) and papillary thyroid carcinoma (PTC). Despite new selective RET tyrosine kinase inhibitors (TKIs), resistance usually occurs and is often driven by RET-independent… read more here.

Keywords: ret src; cancer; ret; ret fusion ... See more keywords

Targeting Nuclear Receptor Coactivator SRC‐1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD‐L1

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202310037

Abstract: Programmed death‐ligand 1 (PD‐L1) is overexpressed in multiple cancers and critical for their immune escape. It has previously shown that the nuclear coactivator SRC‐1 promoted colorectal cancer (CRC) progression by enhancing CRC cell viability, yet… read more here.

Keywords: crc; immune escape; protein; expression ... See more keywords

The revised perceived academic impact tool (PAIT2): A tool to assess academic dysfunction in university‐aged student‐athletes with sports‐related concussion

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recommendations! Published in 2024 at "European Journal of Sport Science"

DOI: 10.1002/ejsc.12051

Abstract: Abstract Research acknowledges Sports‐Related Concussion (SRC) is acutely deleterious to academic ability, but no tool has been validated to measure the effect of SRC on academic ability. The sutdy aimed to establish if the Revised… read more here.

Keywords: student athletes; src; tool; pait2 ... See more keywords

CD55 is upregulated by cAMP/PKA/AKT and modulates human decidualization via Src and ERK pathway and decidualization‐related genes

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recommendations! Published in 2022 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23569

Abstract: Decidualization is an essential process for embryo implantation and maintenance of pregnancy, and abnormal decidualization contributed to several pregnancy disorders like a miscarriage. The objective of this study was to explore the regulation and function… read more here.

Keywords: cd55; expression; decidualization; decidualization related ... See more keywords

Achieving minimal residual disease-negative by multiparameter flow cytometry may ameliorate a poor prognosis in MM patients with high-risk cytogenetics: a retrospective single-center analysis

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recommendations! Published in 2019 at "Annals of Hematology"

DOI: 10.1007/s00277-019-03609-x

Abstract: The aim of our study was to evaluate the prognostic impact of minimal residual disease (MRD) and high-risk cytogenetics (HRCs) on outcomes in multiple myeloma (MM) patients. We applied multiparameter flow cytometry (MFC) to detect… read more here.

Keywords: pfs; risk; minimal residual; mrd ... See more keywords
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DBS is activated by EPHB2/SRC signaling-mediated tyrosine phosphorylation in HEK293 cells

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recommendations! Published in 2019 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-019-03552-5

Abstract: It is well known that Rho family small GTPases (Rho GTPase) has a role of molecular switch in intracellular signal transduction. The switch cycle between GTP-bound and GDP-bound state of Rho GTPase regulates various cell… read more here.

Keywords: rho gtpase; dbs; ephb2 src; src ... See more keywords
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Src mediates β-adrenergic receptor induced YAP tyrosine phosphorylation

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recommendations! Published in 2020 at "Science China Life Sciences"

DOI: 10.1007/s11427-020-1652-9

Abstract: The Hippo pathway is a newly identified pathway and evolutionarily conserved from flies to humans mainly regulating cell proliferation. Transcriptional co-activator Yes-associated protein (YAP) functions as a major downstream effector and key node of the… read more here.

Keywords: tyrosine phosphorylation; src; adrenergic receptor; phosphorylation ... See more keywords
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Association of Abdominal Aortic Aneurysm and Simple Renal Cysts: a Systematic Review and Meta-analysis.

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recommendations! Published in 2021 at "Annals of vascular surgery"

DOI: 10.1016/j.avsg.2021.01.075

Abstract: BACKGROUND-OBJECTIVE Prior studies have suggested a higher prevalence of simple renal cysts (SRC) among patients with aortic disease, including abdominal aortic aneurysms (AAA). Thus, the aim of this study was to systematically review all currently… read more here.

Keywords: analysis; patients aaa; src; simple renal ... See more keywords

Temperature sensitivities of metazoan and pre-metazoan Src kinases

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recommendations! Published in 2020 at "Biochemistry and Biophysics Reports"

DOI: 10.1016/j.bbrep.2020.100775

Abstract: Homologous enzymes from different species display functional characteristics that correlate with the physiological and environmental temperatures encountered by the organisms. In this study, we have investigated the temperature sensitivity of the nonreceptor tyrosine kinase Src.… read more here.

Keywords: src kinases; kinases temperature; temperature; src ... See more keywords

Positive regulatory role of c-Src-mediated TRIM25 tyrosine phosphorylation on RIG-I ubiquitination and RIG-I-mediated antiviral signaling pathway.

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recommendations! Published in 2018 at "Cellular immunology"

DOI: 10.1016/j.cellimm.2018.08.004

Abstract: Retinoic acid-inducible gene I (RIG-I) detects viral RNAs and induces antiviral responses. During viral RNA recognition by RIG-I, tripartite motif protein 25 (TRIM25) plays a critical regulatory role by inducing K63-linked RIG-I polyubiquitination. Previous proteomics… read more here.

Keywords: regulatory role; rig; tyrosine phosphorylation; src ... See more keywords

Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression

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recommendations! Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.02.015

Abstract: Background c-Src is a driver oncogene well-known for tumorigenic signaling, but little for metabolic function. Previous reports about c-Src regulation of glucose metabolism prompted us to investigate its function in other nutrient modulation, particularly in… read more here.

Keywords: inhibition oncogenic; lipolysis; src; cancer ... See more keywords