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   Articles with "src activation" as a keyword



DRIM modulates Src activation and regulates angiogenic functions in vascular endothelial cells

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recommendations! Published in 2024 at "Cell Biology International"

DOI: 10.1002/cbin.12265

Abstract: Downregulated in Metastasis Protein (DRIM) was discovered in malignant epithelial cells and was thought to be mainly a nucleus protein affecting cancer cells. Recent single‐cell sequencing analysis suggests that DRIM is abundantly expressed in vascular… read more here.

Keywords: src activation; vascular endothelial; modulates src; protein ... See more keywords

The type II TGF-β receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling

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recommendations! Published in 2022 at "Science Signaling"

DOI: 10.1126/scisignal.abp9521

Abstract: Transforming growth factor–β (TGF-β) signaling has important roles during embryonic development and in tissue homeostasis. TGF-β ligands exert cellular effects by binding to type I (TβRI) and type II (TβRII) receptors and inducing both SMAD-dependent… read more here.

Keywords: tgf; type; receptor; src activation ... See more keywords

P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.15065

Abstract: Recent studies have demonstrated that P-glycoprotein (P-gp) expression impairs DNA interstrand cross-linking agent-induced DNA repair efficiency in multidrug-resistant (MDR) cells. To date, the detailed molecular mechanisms underlying how P-gp interferes with Src activation and subsequent… read more here.

Keywords: src activation; cbp; dna repair; repair ... See more keywords

Src Activation Aggravates Podocyte Injury in Diabetic Nephropathy via Suppression of FUNDC1-Mediated Mitophagy

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.897046

Abstract: Background and purpose: Mitophagy plays a significant role in the progression of diabetic nephropathy (DN), although the regulatory mechanisms remain unclear. Recently, accumulating evidence demonstrated that impaired mitochondrial function and mitophagy are involved in DN.… read more here.

Keywords: src activation; fundc1 mediated; mediated mitophagy; diabetic nephropathy ... See more keywords