ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.09.033
Abstract: Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The molecular mechanism by which hepatocellular carcinoma (HCC) cells resist anoikis remains not fully understood. Here,… read more here.
Keywords: hcc; fak signaling; anoikis resistance; znf32 ... See more keywords
Cell adhesion suppresses autophagy via Src/FAK-mediated phosphorylation and inhibition of AMPK.
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DOI: 10.1016/j.cellsig.2021.110170
Abstract: Autophagy is a multi-step process regulated in part by AMP-activated protein kinase (AMPK). Phosphorylation of threonine 172 on the AMPK α-subunit enhances AMPK kinase activity, resulting in activation of downstream signaling. Integrin-mediated cell adhesion activates… read more here.
Keywords: cell adhesion; ampk; cell; phosphorylation ... See more keywords
IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma
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DOI: 10.1038/s41416-020-0970-z
Abstract: Background Hepatitis B virus (HBV) has a crucial role in the progression of hepatocellular carcinoma (HCC). Tumour cells must develop anoikis resistance in order to survive before metastasis. This study aimed to investigate the mechanism… read more here.
Keywords: iqgap1; hbv; metastasis; anoikis resistance ... See more keywords