Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2117317
Abstract: Abstract Inhibition of c-Src is considered one of the most studied approaches to cancer treatment, with several heterocyclic compounds approved during the last 15 years as chemotherapeutic agents. Starting from the biological evaluation of an in-house… read more here.
Keywords: synthesis biological; evaluation; potential src; activity ... See more keywords
Abstract 660: Combination of mTOR kinase inhibitors with Src inhibitors in PTEN-mtprostate cancer cells
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DOI: 10.1158/1538-7445.am2020-660
Abstract: Although Src inhibitors are able to suppress malignant functions, their clinical outcomes are modest for the treatment of advanced prostate cancer, many of which harbor mutated PTEN. mTOR pathway is commonly hyperactivated in prostate cancer… read more here.
Keywords: src inhibitors; prostate cancer; mtor; cancer ... See more keywords
Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
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DOI: 10.3390/molecules25184094
Abstract: Src plays a crucial role in many signaling pathways and contributes to a variety of cancers. Therefore, Src has long been considered an attractive drug target in oncology. However, the development of Src inhibitors with… read more here.
Keywords: virtual screening; based virtual; src inhibitors; pharmacophore based ... See more keywords