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   Articles with "src kinase" as a keyword



Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy

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recommendations! Published in 2018 at "Hepatology"

DOI: 10.1002/hep.29400

Abstract: Cystic fibrosis transmembrane conductance regulator (CFTR), the channel mutated in cystic fibrosis (CF), is expressed by the biliary epithelium (i.e., cholangiocytes) of the liver. Progressive clinical liver disease (CF‐associated liver disease; CFLD) occurs in around… read more here.

Keywords: cystic fibrosis; kinase; src kinase; fibrosis transmembrane ... See more keywords

Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration

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recommendations! Published in 2022 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23410

Abstract: The Src tyrosine kinase is a strong tumor promotor. Over a century of research has elucidated fundamental mechanisms that drive its oncogenic potential. Src phosphorylates effector proteins to promote hallmarks of tumor progression. For example,… read more here.

Keywords: cell; growth; kinase; src kinase ... See more keywords

Developing lipophilic aromatic halogenated fused systems with specific ring orientations, leading to potent anticancer analogs and targeting the c-Src Kinase enzyme

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recommendations! Published in 2019 at "Journal of Molecular Structure"

DOI: 10.1016/j.molstruc.2019.03.012

Abstract: Abstract This work presents the combined microwave assisted synthesis, spectroscopic analyses, cytotoxic effects, and molecular docking studies of the chromene fused ring systems with various substituents of the terminal halogenated phenyl ring derivatives of 6-methoxy-4H-benzo… read more here.

Keywords: benzo chromene; kinase; kinase enzyme; src kinase ... See more keywords

Reduced efficacy of a Src kinase inhibitor in crowded protein solution

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-24349-5

Abstract: The inside of a cell is highly crowded with proteins and other biomolecules. How proteins express their specific functions together with many off-target proteins in crowded cellular environments is largely unknown. Here, we investigate an… read more here.

Keywords: inhibitor; kinase; src kinase; crowded protein ... See more keywords

Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-16983-1

Abstract: We have previously shown that cerebral Hypoxia-ischemia (HI) results in activation of Src kinase in the newborn piglet brain. We investigated the regulatory mechanism by which the pre-apoptotic proteins translocate from mitochondria to the cytosol… read more here.

Keywords: hypoxia ischemia; kinase; cytochrome smac; cerebral hypoxia ... See more keywords

Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-33014-9

Abstract: Diabetes mellitus (DM) is a major cardiovascular risk factor contributing to cardiovascular complications by inducing vascular cell dysfunction. Monocyte dysfunction could contribute to impaired arteriogenesis response in DM patients. DM monocytes show blunted chemotactic responses… read more here.

Keywords: dysfunction; src kinase; vegf resistance; shp src ... See more keywords

Design and Optimization of Novel Pyrimidine-Morpholine Hybrids Through Computational Approaches for SRC Kinase Inhibitory Activity

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recommendations! Published in 2025 at "Drug Research"

DOI: 10.1055/a-2554-1119

Abstract: Abstract Src (non receptor tyrosine kinase) plays a role in multiple pathways leading to tumor survival, proliferation and metastasis. Inhibiting Src kinase would be a therapeutic benefit in Src dependent cancers. Most of the nitrogen… read more here.

Keywords: src kinase; morpholine hybrids; novel pyrimidine; pyrimidine morpholine ... See more keywords

Src kinase activation by nitric oxide promotes resistance to anoikis in tumour cell lines

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recommendations! Published in 2018 at "Free Radical Research"

DOI: 10.1080/10715762.2018.1455095

Abstract: Abstract Tumour progression involves the establishment of tumour metastases at distant sites. Resistance to anoikis, a form of cell death that occurs when cells lose contact with the extracellular matrix and with neighbouring cells, is… read more here.

Keywords: nitric oxide; cell; src kinase; resistance anoikis ... See more keywords

Saracatinib, a Src kinase inhibitor, enhances the renoprotective effect of metformin and losartan in diabetic nephropathy

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recommendations! Published in 2025 at "Archives of Physiology and Biochemistry"

DOI: 10.1080/13813455.2024.2449404

Abstract: Abstract Objective This research assesses renoprotective effects of saracatinib (Src) in diabetic nephropathy (DN) and the potential underlying processes. Materials and Methods Rats were divided into: control, DN, DN + Met + Los, DN +… read more here.

Keywords: met los; kinase inhibitor; saracatinib src; diabetic nephropathy ... See more keywords

C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src

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recommendations! Published in 2018 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e17-04-0251

Abstract: The tricellular junction (TCJ) forms at the convergence of three neighboring epithelia. The targeting of Gliotactin, an essential TCJ protein, to the TCJ is controlled by phosphorylation and endocytosis. C-terminal Src kinase controls endocytosis of… read more here.

Keywords: protein; terminal src; src; src kinase ... See more keywords

Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model

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recommendations! Published in 2017 at "NeuroReport"

DOI: 10.1097/wnr.0000000000000835

Abstract: Caspase-2 has features of both initiator and effector caspases. Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases. The… read more here.

Keywords: kinase inhibition; caspase; src kinase; hypoxia ... See more keywords