Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29400
Abstract: Cystic fibrosis transmembrane conductance regulator (CFTR), the channel mutated in cystic fibrosis (CF), is expressed by the biliary epithelium (i.e., cholangiocytes) of the liver. Progressive clinical liver disease (CF‐associated liver disease; CFLD) occurs in around… read more here.
Keywords: cystic fibrosis; kinase; src kinase; fibrosis transmembrane ... See more keywords
Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23410
Abstract: The Src tyrosine kinase is a strong tumor promotor. Over a century of research has elucidated fundamental mechanisms that drive its oncogenic potential. Src phosphorylates effector proteins to promote hallmarks of tumor progression. For example,… read more here.
Keywords: cell; growth; kinase; src kinase ... See more keywords
Developing lipophilic aromatic halogenated fused systems with specific ring orientations, leading to potent anticancer analogs and targeting the c-Src Kinase enzyme
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.03.012
Abstract: Abstract This work presents the combined microwave assisted synthesis, spectroscopic analyses, cytotoxic effects, and molecular docking studies of the chromene fused ring systems with various substituents of the terminal halogenated phenyl ring derivatives of 6-methoxy-4H-benzo… read more here.
Keywords: benzo chromene; kinase; kinase enzyme; src kinase ... See more keywords
Reduced efficacy of a Src kinase inhibitor in crowded protein solution
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24349-5
Abstract: The inside of a cell is highly crowded with proteins and other biomolecules. How proteins express their specific functions together with many off-target proteins in crowded cellular environments is largely unknown. Here, we investigate an… read more here.
Keywords: inhibitor; kinase; src kinase; crowded protein ... See more keywords
Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16983-1
Abstract: We have previously shown that cerebral Hypoxia-ischemia (HI) results in activation of Src kinase in the newborn piglet brain. We investigated the regulatory mechanism by which the pre-apoptotic proteins translocate from mitochondria to the cytosol… read more here.
Keywords: hypoxia ischemia; kinase; cytochrome smac; cerebral hypoxia ... See more keywords
Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33014-9
Abstract: Diabetes mellitus (DM) is a major cardiovascular risk factor contributing to cardiovascular complications by inducing vascular cell dysfunction. Monocyte dysfunction could contribute to impaired arteriogenesis response in DM patients. DM monocytes show blunted chemotactic responses… read more here.
Keywords: dysfunction; src kinase; vegf resistance; shp src ... See more keywords
Src kinase activation by nitric oxide promotes resistance to anoikis in tumour cell lines
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Research"
DOI: 10.1080/10715762.2018.1455095
Abstract: Abstract Tumour progression involves the establishment of tumour metastases at distant sites. Resistance to anoikis, a form of cell death that occurs when cells lose contact with the extracellular matrix and with neighbouring cells, is… read more here.
Keywords: nitric oxide; cell; src kinase; resistance anoikis ... See more keywords
C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-04-0251
Abstract: The tricellular junction (TCJ) forms at the convergence of three neighboring epithelia. The targeting of Gliotactin, an essential TCJ protein, to the TCJ is controlled by phosphorylation and endocytosis. C-terminal Src kinase controls endocytosis of… read more here.
Keywords: protein; terminal src; src; src kinase ... See more keywords
Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000835
Abstract: Caspase-2 has features of both initiator and effector caspases. Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases. The… read more here.
Keywords: kinase inhibition; caspase; src kinase; hypoxia ... See more keywords
The Opposite Effects of ROCK and Src Kinase Inhibitors on Susceptibility of Eukaryotic Cells to Invasion by Bacteria Serratia grimesii
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297919060099
Abstract: Bacterial internalization into eukaryotic cells is ensured by a sophisticated interplay of bacterial and host cell factors. Being a part of cell environment, opportunistic intracellular bacteria have developed various mechanisms providing their interaction with cell… read more here.
Keywords: src kinase; invasion; eukaryotic cells; rock ... See more keywords
Novel regulatory role of post-translational structural modification in modulating Src kinase activity in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5794151
Abstract: Under conditions that lead to pulmonary arterial hypertension (PAH), the pro-proliferative oncoprotein Src kinase activity is elevated, contributing to pulmonary arterial smooth muscle cell remodeling, increasing vascular resistance, and leading to PAH. In addition, reactive… read more here.
Keywords: modification; kinase; src kinase; physiology ... See more keywords