Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103228
Abstract: Conventional antiplatelet agents indiscriminately inhibit both thrombosis and hemostasis, and the increased bleeding risk thus hampers their use at more aggressive dosages to achieve adequate effect. Blocking integrin αIIbβ3 outside‐in signaling by separating the β3/Src… read more here.
Keywords: hemostasis; thrombosis; loop src; src sh3 ... See more keywords
Targeting Src SH3 domain–mediated glycolysis of HSC suppresses transcriptome, myofibroblastic activation, and colorectal liver metastasis
Sign Up to like & getrecommendations! Published in 2024 at "Hepatology"
DOI: 10.1097/hep.0000000000000763
Abstract: Background and Aims: Transforming growth factor-beta 1 (TGFβ1) induces HSC activation into metastasis-promoting cancer-associated fibroblasts (CAFs), but how the process is fueled remains incompletely understood. We studied metabolic reprogramming induced by TGFβ1 in HSCs. Approaches… read more here.
Keywords: sh3 domain; src sh3; glut1; activation ... See more keywords