Exosomal miR‐122 promotes adipogenesis and aggravates obesity through the VDR/SREBF1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23365
Abstract: This study examined the effects of miR‐122–enriched exosomes on the expression of vitamin D3 receptor (VDR) and sterol regulatory element‐binding transcription factor 1 (SREBF1) and their roles during adipogenesis. read more here.
Keywords: 122 promotes; obesity; exosomal mir; vdr ... See more keywords
Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.090
Abstract: Recent evidence has revealed a novel signaling mechanism through which brown adipose tissue (BAT)-derived exosomal microRNAs (miRNAs) influence hepatic gene expression. Here, we uncover neuronal control of these miRNAs and identify exosomal miR-132-3p as a… read more here.
Keywords: mir 132; srebf1; derived exosomal; expression ... See more keywords
Sterol regulatory element binding transcription factor 1 promotes proliferation and migration in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.15203
Abstract: Background Sterol-regulatory element-binding protein 1 (SREBP1) is a transcription factor involved in lipid metabolism that is encoded by sterol regulatory element binding transcription factor 1(SREBF1). SREBP1 overexpression is associated with the progression of several human… read more here.
Keywords: cell; proliferation migration; hnsc; srebf1 ... See more keywords