GPRC6A is a key mediator of palmitic acid regulation of lipid synthesis in bovine mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11886
Abstract: Fatty acids (FAs) can promote lipid synthesis in the mammary gland via stimulating lipogenic gene expression, but the underlying molecular mechanism is still not fully understood. Here, we showed the dose‐dependent effects of palmitic acid… read more here.
Keywords: lipid synthesis; srebp; synthesis; expression ... See more keywords
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-020-00753-3
Abstract: Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved… read more here.
Keywords: protease; srebp; site protease; c12orf49 ... See more keywords
Regulatory roles of sterol regulatory element-binding protein (SREBP) on lipid metabolism in marine invertebrate Chlamys nobilis.
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2018.03.023
Abstract: Abstract Sterol regulatory element-binding protein (SREBP) has mainly been studied in vertebrates in which lipogenesis is regulated in both liver and adipose tissue. There is, however, a paucity of information on bivalves, in which lipogenesis… read more here.
Keywords: regulatory element; srebp; protein srebp; binding protein ... See more keywords
Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.11.004
Abstract: Accumulation of matrix in the glomerulus is a classic hallmark of diabetic nephropathy. The profibrotic cytokine transforming growth factor beta 1 (TGF-β1) plays a central role in the development of glomerular sclerosis. Recent studies have… read more here.
Keywords: secretion; srebp; tgf; receptor ... See more keywords
Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.11.069
Abstract: During differentiation, neurons require a high lipid supply for membrane formation as they elaborate complex dendritic morphologies. While glia-derived lipids support neuronal growth during development, the importance of cell-autonomous lipid production for dendrite formation has been… read more here.
Keywords: production; dendrite expansion; fatty acid; srebp ... See more keywords
Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.
Sign Up to like & getrecommendations! Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2016.12.017
Abstract: Sterol regulatory element-binding proteins (SREBPs) are transcription factors that control lipid homeostasis. SREBP activation is regulated by a negative feedback loop in which sterols bind to SREBP cleavage-activating protein (SCAP), an escort protein essential for… read more here.
Keywords: degradation; srebp; scap; srebp activation ... See more keywords
Electroacupuncture ameliorates poloxamer 407‐induced hyperlipidemia through suppressing hepatic SREBP‐2 expression in rats
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.04.016
Abstract: Aims: Acupuncture, particularly electroacupuncture (EA) has been shown to have the lipid‐lowering effects, but not completely investigated. The present study was aimed to examine whether EA could attenuate poloxamer‐407 (P‐407)‐induced hyperlipidemia in the rats and… read more here.
Keywords: srebp; 407 induced; expression; poloxamer 407 ... See more keywords
Novel insights for SREBP-1 as a key transcription factor in regulating lipogenesis in a freshwater teleost, grass carp Ctenopharyngodon idella
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Nutrition"
DOI: 10.1017/s0007114519001934
Abstract: Abstract Disturbances in lipid metabolism are at the core of several health issues facing modern society, including fatty liver and obesity. The sterol regulatory element-binding protein 1 (SREBP-1) is one important transcription factor regulating lipid… read more here.
Keywords: ctenopharyngodon idella; srebp; transcription; promoter ... See more keywords
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Mediators of Inflammation"
DOI: 10.1155/2021/5754592
Abstract: Background Hepatoblastoma (HB) is the most common liver malignancy in pediatrics, but the treatment for this disease is minimal. This study is aimed at exploring the effect of FoxO1 and SREBP-1c on HB and their… read more here.
Keywords: acid metabolism; foxo1 srebp; fatty acid; foxo1 ... See more keywords
Abstract 1457: SCAP/SREBP-1 regulates lipid metabolism reprogramming in cancer cell
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1457
Abstract: Warburg initial observation shows tumorigenesis is associated with an increased glucose consumption. Recently, accumulating evidence show that lipid metabolism is reprogrammed in cancers. Elevated lipogenesis which contributes to the development of malignant phenotypes is known… read more here.
Keywords: srebp; scap; cancer cell; cancer ... See more keywords
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-03179
Abstract: Sterol regulatory element-binding protein (SREBP)-1a is a key transcription factor that activates the expression of genes involved in the synthesis of fatty acids, triglycerides (TGs), and cholesterol. Transgenic mice that overexpress the nuclear form of… read more here.
Keywords: transgenic mice; srebp; mice; insulin resistance ... See more keywords