Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.
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DOI: 10.1016/j.chembiol.2016.12.017
Abstract: Sterol regulatory element-binding proteins (SREBPs) are transcription factors that control lipid homeostasis. SREBP activation is regulated by a negative feedback loop in which sterols bind to SREBP cleavage-activating protein (SCAP), an escort protein essential for… read more here.
Keywords: degradation; srebp; scap; srebp activation ... See more keywords
Aβ inhibits SREBP-2 activation through Akt inhibition
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DOI: 10.1194/jlr.m076703
Abstract: We previously demonstrated that oligomeric amyloid β42 (oAβ42) inhibits the mevalonate pathway impairing cholesterol synthesis and protein prenylation. Enzymes of the mevalonate pathway are regulated by the transcription factor SREBP-2. Here, we show that in… read more here.
Keywords: akt; mevalonate pathway; inhibition; srebp activation ... See more keywords