LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23538
Abstract: Abnormal cholesterol synthesis plays a crucial role in the development of hepatocellular carcinoma (HCC). Sterol regulatory element-binding protein 2 (SREBP2) is involved in cholesterol synthesis by translocating to the nucleus where it stimulates the transcription… read more here.
Keywords: hepatocellular carcinoma; translocation; hcc; migration invasion ... See more keywords
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac297
Abstract: Abstract Abnormal lipid homeostasis has been observed in the brain of Parkinson’s disease (PD) patients and experimental models, although the mechanism underlying this phenomenon is unclear. Notably, previous studies have reported that the PD-linked protein… read more here.
Keywords: lipid homeostasis; parkinson disease; srebp2; homeostasis ... See more keywords
PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-24-0866
Abstract: Identities of functional pSer/Thr.Pro protein substrates of the PIN1 prolyl isomerase and its effects on downstream signaling in bladder carcinogenesis remain largely unknown. Phenotypically, we found that PIN1 positively regulated bladder cancer cell proliferation, cell… read more here.
Keywords: cancer; pin1; srebp2; bladder cancer ... See more keywords
Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.990672
Abstract: The sterol regulatory-element binding proteins (SREBPs) are transcription factors controlling cholesterol and fatty acid synthesis and metabolism. There are three SREBP proteins, SREBP1a, SREBP1c and SREBP2, with SREBP1a being the strongest transcription factor. The expression… read more here.
Keywords: cancer; fbw7; loss; srebp2 ... See more keywords
Mechanism of protecting hepatocytes in NAFLD through MST1-FOXO3a-SREBP2 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Endokrynologia Polska"
DOI: 10.5603/ep.103350
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent chronic liver condition, primarily characterized by excessive accumulation of fat within the liver. A pivotal factor in the progression of NAFLD is cholesterol deposition, which significantly… read more here.
Keywords: srebp2; foxo3a srebp2; mst1 foxo3a; mechanism protecting ... See more keywords
Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.60467
Abstract: Myelination depends on timely, precise control of oligodendrocyte differentiation and myelinogenesis. Cholesterol is the most abundant component of myelin and essential for myelin membrane assembly in the central nervous system. However, the underlying mechanisms of… read more here.
Keywords: srebp2; myelinogenesis; cholesterol biosynthesis; cholesterol ... See more keywords