Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.03.031
Abstract: Abstract The mammalian target of rapamycin (mTOR)-sterol regulatory element-binding proteins (SREBPs) signaling promotes lipogenesis. However, mTOR inhibitors also displayed a significant side effect of hyperlipidemia. Thus, it is essential to develop mTOR-specific inhibitors to inhibit… read more here.
Keywords: srebps pathway; hyperlipidemia; p70s6k srebps; mtor ... See more keywords
Zexie Tang targeting FKBP38/mTOR/SREBPs pathway improves hyperlipidemia.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115101
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Zexie Tang (ZXT), only two consists with Alismatis Rhizoma (AR) and Atractylodes macrocephala Rhizoma (AM), a classical Chinese medicine formula from Synopsis of the Golden Chamber with a history of 2000 years. Clinical… read more here.
Keywords: srebps pathway; mtor srebps; zexie tang; fkbp38 mtor ... See more keywords