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   Articles with "srna" as a keyword



Efficient gene knockdown in Clostridium acetobutylicum by synthetic small regulatory RNAs

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recommendations! Published in 2017 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.26077

Abstract: Clostridium is considered a promising microbial host for the production of valuable industrial chemicals. However, Clostridium is notorious for the difficulty of genetic manipulations, and consequently metabolic engineering. Thus, much effort has been exerted to… read more here.

Keywords: srna; acetobutylicum; clostridium; expression ... See more keywords

A novel synthetic sRNA promoting protein overexpression in cell-free systems.

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recommendations! Published in 2023 at "Biotechnology progress"

DOI: 10.1002/btpr.3324

Abstract: Bacterial small RNAs (sRNAs) that regulate gene expression have been engineered for uses in synthetic biology and metabolic engineering. Here, we designed a novel non-Hfq-dependent sRNA scaffold that makes use of a 20 nt antisense… read more here.

Keywords: cell free; novel synthetic; expression; srna ... See more keywords

Bencaosome [16:0 Lyso PA+XLGB28‐sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice

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recommendations! Published in 2024 at "IUBMB Life"

DOI: 10.1002/iub.2857

Abstract: Osteoporosis (OP) is a systemic metabolic bone disease resulting in reduced bone strength and increased susceptibility to fractures, making it a significant public health and economic problem worldwide. The clinical use of anti‐osteoporosis agents is… read more here.

Keywords: mice; srna; simultaneously promoting; xlgb28 srna ... See more keywords

Hfq chaperone brings speed dating to bacterial sRNA

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recommendations! Published in 2018 at "Wiley Interdisciplinary Reviews: RNA"

DOI: 10.1002/wrna.1475

Abstract: Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea. Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their mRNA targets, and directly binds and regulates… read more here.

Keywords: hfq; chaperone brings; srna; rna ... See more keywords

Small RNA in sperm–Paternal contributions to human embryo development

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-62015-2

Abstract: Sperm not only delivers the paternal genome to the oocyte but also regulatory small RNA (sRNA). However, the role of sRNA in fertilisation and human embryo development remains poorly understood. Here, couples undergoing IVF are… read more here.

Keywords: srna; human embryo; small rna; embryo development ... See more keywords

Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response

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recommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1718003115

Abstract: Significance This work describes the most extensive discovery and functional characterization of small regulatory RNAs (sRNAs) in Mycobacterium tuberculosis to date. We comprehensively define the sRNAs expressed in M. tuberculosis under five host-like stress conditions.… read more here.

Keywords: response; srna; tuberculosis; iron sparing ... See more keywords
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Gene repression using synthetic small regulatory RNA in Methylorubrum extorquens.

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recommendations! Published in 2021 at "Journal of applied microbiology"

DOI: 10.1111/jam.15159

Abstract: AIM Genetic tools are a prerequisite for engineering cell factories for synthetic biology and biotechnology. Methylorubrum extorquens is an important platform for a future one-carbon (C1) bioeconomy, but its application is currently limited by the availability… read more here.

Keywords: gene repression; srna; methylorubrum extorquens; rna ... See more keywords
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Probing the sRNA regulatory landscape of P. aeruginosa: post‐transcriptional control of determinants of pathogenicity and antibiotic susceptibility

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recommendations! Published in 2017 at "Molecular Microbiology"

DOI: 10.1111/mmi.13857

Abstract: During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We extended the use of the in vivo RNA proximity ligation method toward probing… read more here.

Keywords: srna; srna regulatory; probing srna; aeruginosa post ... See more keywords

The functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin-tolerant Staphylococcus aureus

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recommendations! Published in 2024 at "mSystems"

DOI: 10.1128/msystems.00971-23

Abstract: ABSTRACT Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution… read more here.

Keywords: srna; treatment; cell wall; srna mrna ... See more keywords

Identification and Regulatory Roles of a New Csr Small RNA from Arctic Pseudoalteromonas fuliginea BSW20308 in Temperature Responses

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recommendations! Published in 2023 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.04094-22

Abstract: Previous research on microbial temperature adaptation has focused primarily on functional genes, with little attention paid to posttranscriptional regulation. Small RNAs, the major posttranscriptional modulators of gene expression, are greatly underexplored, especially in nonpathogenic and… read more here.

Keywords: srna; temperature; fuliginea bsw20308; gene expression ... See more keywords

Identification of oligo-adenylated small RNAs in the parasite Entamoeba and a potential role for small RNA control

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recommendations! Published in 2020 at "BMC Genomics"

DOI: 10.1186/s12864-020-07275-6

Abstract: Background The RNA interference (RNAi) pathway is a gene regulation mechanism that utilizes small RNA (sRNA) and Argonaute (Ago) proteins to silence target genes. Our previous work identified a functional RNAi pathway in the protozoan… read more here.

Keywords: small rna; non templated; srna; parasite entamoeba ... See more keywords