Sushi repeat‐containing protein X‐linked 2: A novel phylogenetically conserved hypothalamo‐pituitary protein
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24449
Abstract: Sushi repeat‐containing protein X‐linked 2 (SRPX2) is a novel protein associated with language development, synaptic plasticity, tissue remodeling, and angiogenesis. We investigated the expression and spatial localization of SRPX2 in normal mouse, rat, monkey, and… read more here.
Keywords: protein; srpx2; protein linked; sushi repeat ... See more keywords
Exploring the association between SRPX2 variants and neurodevelopment: How causal is it?
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.10.067
Abstract: The SRPX2 gene (Sushi-repeat-containing protein, X-linked, 2, OMIM*300642), located on Xq22.1, encodes a secreted protein that is highly expressed in neurons of cerebral cortex. SRPX2 was first implicated in neurodevelopment, learning and rolandic seizure when… read more here.
Keywords: srpx2 variants; association srpx2; srpx2; speech language ... See more keywords
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
Sign Up to like & getrecommendations! Published in 2020 at "Nature neuroscience"
DOI: 10.1038/s41593-020-0672-0
Abstract: Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons express complement inhibitors that protect synapses against complement-mediated synapse elimination remains unknown. Here, we show that… read more here.
Keywords: elimination; srpx2; synapse elimination; complement mediated ... See more keywords