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   Articles with "srsf1" as a keyword



SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia

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recommendations! Published in 2020 at "Leukemia"

DOI: 10.1038/s41375-020-0732-1

Abstract: Patients with chronic myeloid leukemia (CML) who are treated with tyrosine kinase inhibitors (TKIs) experience significant heterogeneity regarding depth and speed of responses. Factors intrinsic and extrinsic to CML cells contribute to response heterogeneity and… read more here.

Keywords: cml; imatinib sensitivity; impaired imatinib; srsf1 ... See more keywords

SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer

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recommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-021-00495-6

Abstract: Alternative splicing is a critical process to generate protein diversity. However, whether and how alternative splicing regulates autophagy remains largely elusive. Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor. Specifically, SRSF1… read more here.

Keywords: srsf1; cancer; bcl; beclin1 pik3c3 ... See more keywords

Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation.

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recommendations! Published in 2017 at "Cancer research"

DOI: 10.1158/0008-5472.can-16-1508

Abstract: Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA MALAT1 is upregulated in hepatocellular carcinoma and acts as a proto-oncogene… read more here.

Keywords: hepatocellular carcinoma; malat1; mtor; activation ... See more keywords

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer.

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recommendations! Published in 2023 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-22-1013

Abstract: Inflammation is strongly associated with pancreatic ductal adenocarcinoma (PDAC), a highly lethal malignancy. Dysregulated RNA splicing factors have been widely reported in tumorigenesis, but their involvement in pancreatitis and PDAC is not well understood. Here,… read more here.

Keywords: krasg12d mediated; factor srsf1; srsf1; krasg12d ... See more keywords

Endothelial SRSF1 Promotes Ischemia-Induced Angiogenesis via ATF3-KLF2-S1PR1 Pathway.

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recommendations! Published in 2025 at "Circulation research"

DOI: 10.1161/circresaha.125.326391

Abstract: BACKGROUND Peripheral artery disease is a severe ischemic vascular pathology without effective pharmacological approaches and improving angiogenesis to recover blood perfusion is a promising therapeutic strategy. Endothelial cells are the primary cell type contributing to… read more here.

Keywords: srsf1; angiogenesis; endothelial srsf1; ischemia induced ... See more keywords

Binding of FANCD2 to SRSF1 Splicing Factor Prevents Genomic Instability through R Loop Regulation

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-141369

Abstract: BACKGROUND. Fanconi Anemia (FA) is a rare disease characterized by congenital abnormalities, bone marrow failure and cancer susceptibility. The pivotal role of the FA pathway is DNA interstrand crosslink (ICL) repair, where FANCD2-FANCI complex monoubiquitination… read more here.

Keywords: genomic instability; srsf1; fancd2 srsf1; loop ... See more keywords

Low expressed SRSF1 promotes lck exon 8 skipping to attenuate TCR signaling and treg induction in immune thrombocytopenia

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-4779

Abstract: Introduction: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by platelet destruction and impaired production. A key feature involves dysfunctional immune regulation, particularly impaired regulatory T cell (Treg) frequency and function. While Treg deficiencies in… read more here.

Keywords: treg induction; srsf1; tcr signaling; lck ... See more keywords

High expression of SRSF1 facilitates osteosarcoma progression and unveils its potential mechanisms

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recommendations! Published in 2024 at "BMC Cancer"

DOI: 10.1186/s12885-024-12346-y

Abstract: SRSF1, a member of Serine/Arginine-Rich Splicing Factors (SRSFs), has been observed to significantly influence cancer progression. However, the precise role of SRSF1 in osteosarcoma (OS) remains unclear. This study aims to investigate the functions of… read more here.

Keywords: srsf1; progression; srsf1 expression; analysis ... See more keywords

SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis

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recommendations! Published in 2025 at "Journal of Translational Medicine"

DOI: 10.1186/s12967-025-06547-7

Abstract: Alternative splicing (AS) is consistently linked to tumor progression. SRSF1, the first identified proto-oncogene in the serine/arginine-rich splicing factor (SRSF) protein family, plays a crucial role. However, the specific functions and potential mechanisms of SRSF1… read more here.

Keywords: hif1a bnip3; srsf1; alternative splicing; cisplatin ... See more keywords

SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.838719

Abstract: The underlying mechanisms of thymocyte development and lineage determination remain incompletely understood, and the emerging evidences demonstrated that RNA binding proteins (RBPs) are deeply involved in governing T cell fate in thymus. Serine/arginine-rich splicing factor… read more here.

Keywords: thymocyte maturation; srsf1; fate; lineage ... See more keywords

LncRNA KASRT Serves as a Potential Treatment Target by Regulating SRSF1-Related KLF6 Alternative Splicing and the P21/CCND1 Pathway in Osteosarcoma: An In Vitro and In Vivo Study

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.700963

Abstract: Purpose Long non-coding RNA KLF6 alternative splicing regulating transcript (lnc-KASRT) locates within the intronic region of SRSF1, possessing the potential to regulate KLF6 alternative splicing to promote carcinogenicity. Then, the current in vitro and in… read more here.

Keywords: lnc kasrt; klf6 alternative; srsf1; alternative splicing ... See more keywords