Single‐Cell RNA Sequencing Reveals Heterogeneity of Myf5‐Derived Cells and Altered Myogenic Fate in the Absence of SRSF2
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DOI: 10.1002/advs.202105775
Abstract: Splicing factor SRSF2 acts as a critical regulator for cell survival, however, it remains unknown whether SRSF2 is involved in myoblast proliferation and myogenesis. Here, knockdown of SRSF2 in myoblasts causes high rates of apoptosis… read more here.
Keywords: cell; myf5 derived; absence; fate ... See more keywords
Clinical Outcomes Following Frontline Chemotherapy for Patients with Myeloid Malignancies Harboring Splicing Factor Mutations
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DOI: 10.1182/blood-2018-99-111982
Abstract: Background Recurrent mutations in the spliceosome complex are seen in myeloid malignancies, including acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), and myelodysplastic syndromes (MDS). Mutations are detected most frequently in SF3B1, SRSF2, or U2AF1,… read more here.
Keywords: chemotherapy; difference; treatment; disease ... See more keywords
Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia
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DOI: 10.18632/oncotarget.15355
Abstract: Chronic neutrophilic leukemia (CNL) and chronic myelomonocytic leukemia (CMML) are rare hematologic neoplasms. We performed CSF3R, SRSF2 and SETBP1 mutational analyses in 10 CNL and 56 CMML patients. In this sample cohort, 80% of CNL… read more here.
Keywords: cmml patients; setbp1; srsf2; csf3r ... See more keywords