Clinical implications of SRSF2 mutations in AML patients undergoing allogeneic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26298
Abstract: The SRSF2 mutations are frequently found in acute myeloid leukemia (AML) and mostly affect the P95 residue. Mutations in this splicing factor mediate abnormal splicing associated with exon skipping events, including EZH2 as a crucial… read more here.
Keywords: aml patients; hsct; clinical implications; implications srsf2 ... See more keywords
Altered expression of CSF3R splice variants impacts signal response and is associated with SRSF2 mutations
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0567-9
Abstract: Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with AML. CSF3R-V3 mRNA was identified in placenta more than 20… read more here.
Keywords: splice variants; expression csf3r; expression; csf3r ... See more keywords