Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.11.001
Abstract: Myelodysplastic syndromes (MDS) and related myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are clonal stem cell disorders, primarily affecting patients over 65 years of age. Mapping of the MDS and MDS/MPN genome identified recurrent heterozygous mutations in the RNA… read more here.
Keywords: murine models; modeling human; human rna; sf3b1 srsf2 ... See more keywords
Effect of RNA splicing machinery gene mutations on prognosis of patients with MDS
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000015743
Abstract: Abstract Background: Gene mutations with important prognostic role have been identified in patients with myelodysplastic syndrome (MDS). We performed a meta-analysis to investigate the effects of RNA splicing machinery gene mutations on prognosis of MDS… read more here.
Keywords: gene mutations; srsf2 u2af1; effect; group ... See more keywords