1004 - HOW DO SRSF2P95H MUTATIONS LEAD TO MYELODYSPLASTIC/MYELOPROLIFERATIVE SYNDROME (MDS/MPN)?
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.242
Abstract: SRSF2 P95 mutations are prevalent in myelodysplastic (MDS) and myelodysplastic/myeloproliferative (MDS/MPN) syndromes. They occur early in the course of the disease, are positively selected during disease progression and are associated with poor outcomes. Understanding how… read more here.
Keywords: mds; myelodysplastic myeloproliferative; mds mpn; srsf2p95h ... See more keywords
3149 – DNA REPAIR AND CELL CYCLE ARE SYNTHETIC LETHAL PATHWAYS IN SRSF2P95H MUTATED CELLS
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DOI: 10.1016/j.exphem.2020.09.156
Abstract: Current strategies to target cells with mutations in the RNA splicing machinery have focused on the disruption of normal splicing activities. However, splicing inhibitors are also toxic to wild-type cells as has been demonstrated in… read more here.
Keywords: dna repair; repair cell; cell; srsf2p95h ... See more keywords