Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis
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DOI: 10.1038/s41389-024-00539-w
Abstract: SS18-SSX onco-fusion protein formed through aberrant chromosomal translocation t (X, 18; p11, q11), is the hallmark and plays a critical role in synovial sarcomagenesis. The recent works indicated that both the pathological SS18-SSX tumorigenic fusion… read more here.
Keywords: ss18; synovial sarcomagenesis; ss18 ssx; protein ... See more keywords
Abstract 2975: Synthetic lethality in synovial sarcoma: SS18-SSX fusions and DNA damage response (DDR) inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2975
Abstract: Aim: Synovial sarcoma (SS) is an aggressive soft-tissue malignancy predominantly affecting the young and characterised by pathognomonic SS18-SSX fusions. Treatment options are limited and therapeutic targeting of SS18-SSX oncoproteins has not yet been achieved. We… read more here.
Keywords: response; sensitivity; ss18 ssx; ss18 ... See more keywords